Abstract:【Objective】To investigate the effect of femtosecond laser in cataract ultrasonic emulsification operation. 【Methods】Two hundred and eighty-two cases (297 eyes) of patients underwent cataract ultrasonic emulsification operation in our hospital from January 2014 to December 2015 were divided according to the different operation mode into femtosecond laser assisted group (the observation group,157 cases with 161 eyes) and the traditional ultrasonic phacoemulsification group (125 cases of 136 eyes).The observation group was treated with ultrasonic phacoemulsification assisted with femtosecond laser , while the control group with traditional ultrasonic phacoemulsification therapy .The process of the operation of the average ultrasonic energy(AVE), the effective phaco time(EPT), the surgical induced astigmatism 2 months postoperation(SIA), the best corrected visual acuity(BCVA), corneal endothelial cells lost rate and complications were observed and recorded. 【Results】 The average ultrasonic energy (AVE) in the process of operation of the femtosecond laser group was 6.5± 2.1% ,which was significantly less than that of the conventional phacoemulsification group 10.0±1.5%, the EPT was (6.1±2)s , which was significantly shorter than that of the control group (8.2 ±1.5)s, the difference was statistically significant (P<0.01). In the observation group, the SIA two months after operation was significantly less than that of the control group, the difference was statistically significant(P<0.05). There was no significant difference in BCVA between the two groups (P>0.05); The corneal endothelial cell loss rate in the observation group was (8.4 ±4.3)%, which was significantly lower than that of the control group (15.9 ±7.4)%, the difference was statistically significant (P<0.05); no serious complications occurred in the two groups.【Conclusion】 Femtosecond laser assistance is an effective and safe approach in cataract ultrasonic emulsification operation, which is able to reduce AVE and EPT significantly, minimize SIA and the loss rate of corneal endothelium. It is worthy of clinical popularization and application.