双歧杆菌四联活菌联合谷维素治疗女性肠易激综合征的疗效及对患者血清TNF- α、IL- 6的影响

doi:10.3969/j.issn.1671-7171.2016.11.019

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摘要【目的】探讨双歧杆菌四联活菌联合谷维素治疗女性肠易激综合征的疗效及其对患者血清TNF- α、IL- 6的影响。【方法】肠易激综合征患者86例,随机分为两组,每组43例。对照组:给予常规支持治疗。观察组:在对照组常规治疗的基础上加用谷维素及双歧杆菌四联活菌治疗。比较两组临床疗效,精神状态及炎性因子水平。【结果】观察组总有效率为95.35%高于对照组总有效率72.09%,差异具有统计学意义(P＜0.01)。治疗后,观察组患者症状严重程度、症状频率评分均低于对照组,差异均有统计学意义(P＜0.01)。治疗后,观察组汉密尔顿抑郁量表(HAMD)评分(10.41±2.50)分和和汉密尔顿焦虑量表(HAMA)评分(10.24±2.68)分低于对照组HAMD评分(12.92±3.16)分和HAMA评分(12.63±3.35)分,差异具有统计学意义(P＜0.01)。治疗后,观察组血清TNF- α水平(29.72±11.75) pg/mL、IL- 6(11.23±3.15)ng/L均低于对照组血清TNF- α水平(43.56±12.47) pg/mL、IL- 6(17.91±4.17)ng/L,差异均有统计学意义(P＜0.01)。【结论】双歧杆菌四联活菌联合谷维素用于治疗肠易激综合征疗效确切,可有效改善胃肠道功能及血清TNF- α、IL- 6水平,提高患者生活质量。

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关键词 ：肠易激综合征, 有益菌种/治疗应用, 香豆酸类/治疗应用, 植物甾醇类/治疗应用, 片剂, 肿瘤坏死因子-α, 白细胞介素6

Abstract：【Objective】To investigate the effect of bifidobacterium quadruplex living bacterium combined with oryzanol in the treatment of irritable bowel syndrome and its influence on serum levels of TNF- alpha and IL-6. 【Methods】A total of 86 cases of patients with irritable bowel syndrome were randomly divided into a control group and an observation group, with n=43 cases in each group. The control group was given routine treatment, while the observation group was given treatment by bifidobacterium quadruple living bacterium combined with oryzanol. 【Results】 The total effective rate of the observation group was higher than that of the control group (95.35% vs 72.09%); the difference had statistical significance (P<0.01). After the treatment, the symptom severity score and frequency of symptoms score of the observation group were lower than of the control group; there was a statistically significant difference (P<0.01). After treatment, the HAMD score (10.41 ± 2.50) points, HAMA score (10.24 ± 2.68) points of the observation group were lower than HAMD (12.92 ± 3.16) score points and HAMA score (12.63 ± 3.35) points of the control group, and there was a statistically significant difference (P<0.01). After treatment, the serum levels of TNF-α (29.72 ± 11.75) pg/mL, IL-6 (11.23 ± 3.15) ng/ L of the observation group were lower than the serum levels of TNF-α (43.56 ± 12.47) pg/mL, IL-6 (17.91 ± 4.17) ng/L of the control group; the differences had statistical significance (P<0.01). 【Conclusion】The curative effect of the bifidobacterium quadruplex living bacterium combined with oryzanol in the treatment of irritable bowel syndrome was good; it can effectively improve the gastrointestinal function and the serum levels of TNF-α and IL-6 to improve the quality of life.

Key words： Irritable Bowel Syndrome Probiotics/TU Coumaric Acids/TU Phytosterols/TU Tablets Tumor Necrosis Factor-alpha Interleukin-6

收稿日期: 2016-09-07

PACS:

R574

通讯作者: 曾文

引用本文:

曾文. 双歧杆菌四联活菌联合谷维素治疗女性肠易激综合征的疗效及对患者血清TNF- α、IL- 6的影响[J]. 医学临床研究, 2016, 33(11): 2136-2139.
ZENG Wen. Study on the Influence of Bifidobacterium Quadruplex Combined with Oryzanol on Serum Levels of TNF-α、IL-6 in Female Patients with Irritable Bowel Syndrome. JOURNAL OF CLINICAL RESEARCH, 2016, 33(11): 2136-2139.

链接本文:

http://www.jcr.net.cn/CN/10.3969/j.issn.1671-7171.2016.11.019 或 http://www.jcr.net.cn/CN/Y2016/V33/I11/2136

[1] Haller D.Guidance for substantiating the evidence for beneficial effects of probiotics: probiotics in chronic inflammatory bowel disease and the functional disorder irritable bowel syndrome[J].J Nutr,2010,140(3):671S- 676S.
[2] Shekhar C.Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin[J].Gastroenterology,2013,145(4):749- 757.
[3] 岑永豪.双歧杆菌四联活菌联合谷维素治疗肠易激综合征的临床观察[J].实用药物与临床,2013,16(1):22- 24.
[4] 冯飞琴.曲美布汀对肠易激综合征患者IL- 18、IL- 10和TNF- α水平的影响及疗效观察[J].中国药师,2014,17(1):108- 110.
[5] 庄李磊,胡团敏,黄思付,等.黄术灌肠液对肠易激综合征患者TNF- α表达的影响[J].世界华人消化杂志,2014,22(1):144- 148.
[6] 廖如奕,牛灵. 马来酸曲美布汀与枯草杆菌二联活菌肠溶胶囊联合对肠易激综合症的疗效及对白细胞介素- 6的影响[J].中国临床药理学杂志,2011,27(10):743- 745.
[7] 王媛媛.“痛泻抑肝散”治疗肠易激综合征腹泻型30例临床观察[J].江苏中医药,2012,44(08):16- 17.
[8] Rachel Hutchins,Thomas Kyle,Allmond. Linaclotide (Linzess) for Irritable Bowel syndrome With Constipation and For Chronic Idiopathic Constipation[J].P T,2013,38(3):154- 160.
[9] 张强,周超,喻斌.肠安泻愈汤联合马来酸曲美布汀胶囊治疗腹泻型肠易激综合征54例临床观察[J].中医杂志,2014,55(3):225- 227.
[10] 李乾,吴娟,李新华,等.米氮平联合匹维溴胺治疗腹泻型肠易激综合征的疗效及相关机制研究[J].中国现代医学杂志,2012,22(7):52- 55.
[11] 杨卫红,昌菁,卢维晟,等.匹维溴胺联合谷维素治疗老年肠易激综合征临床疗效观察[J].中国医药导报,2011,8(31):97- 98,101.
[12] 刘虹雯,席智文.匹维溴胺联合氟哌噻吨美利曲辛治疗肠易激综合征伴抑郁状态疗效观察[J].中国医药,2009,4(8):579- 580.
[13] 王谦,朱雁兵,佟博,等.马来酸曲美布汀、谷维素联合心理干预治疗老年肠易激综合征58例[J].中国老年学杂志,2012,32(19):4332- 4333.
[14] 魏晓晶,王佩蓉.肠易激综合征各亚型患者的抑郁焦虑状况及其影响因素分析[J].中国现代医生,2014,52(28):134- 137.
[15] 张璐,段丽萍,刘懿萱,等.中国人群肠易激综合征患病率和相关危险因素的Meta分析[J].中华内科杂志,2014,53(12):969- 975.
[16] 李华茹.马来酸曲美布汀联合双歧双联活菌对老年肠易激综合征患者血清IL- 6、IL- 12和IL- 18的影响[J].中国老年学杂志,2012,32(8):1741- 1742.
[17] Michael,Camilleri Karen,Lasch Wen,et al. Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome[J].Am J Physiol Gastrointest Liver Physiol,2012,303(7):G775- 785.
[18] 邬文伟. 右旋糖酐铁联合合生元益生菌治疗小儿营养性缺铁性贫血的前瞻性研究[J].中国妇幼保健,2014,29(20):3284- 3286.
[19] 周正华,马玲玲.肠易激综合征与神经- 内分泌- 免疫网络关系[J].中国中西医结合消化杂志,2013,21(2):106- 109.
[20] Pellissier S , Dantzer C , Mondillon L , et al. Relationship between vagal tone, cortisol, TNF- alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome[J].PLoS One,2014,9(9):e105328.
[21] Feng JS , Yang Z , Zhu YZ , et al .Serum IL- 17 and IL- 6 increased accompany with TGF- β and IL- 13 respectively in ulcerative colitis patients[J].Int J Clin Exper Med,2014 ,7 (12):5498- 5504.