摘要【目的】观察右美托咪定联合丙泊酚在无痛纤维结肠镜检查中的应用效果。【方法】本院行无痛纤维结肠镜检查的患者100例,根据麻醉方案不同分为对照组(n=50)和观察组(n=50)。对照组采用丙泊酚联合舒芬太尼麻醉,观察组采用右美托咪定联合丙泊酚麻醉,比较两组麻醉效果及安全性。【结果】观察组手术时间、苏醒时间、离院时间均显著短于对照组,且两组相比较差异有显著性(P<0.05);观察组丙泊酚使用剂量显著少于对照组(P<0.05);两组术前视觉模拟评分(VAS)相比较差异无显著性(P>0.05);观察组术后0.5 h、4 h及8 h VAS评分显著低于对照组(P<0.05);观察组术后并发症发生率为8.0%(4/50),低于对照组的24.0%(12/50)(P<0.05)。【结论】与丙泊酚联合舒芬太尼麻醉相比,无痛纤维结肠镜检查中采用右美托咪定联合丙泊酚麻醉效果更为理想,安全性较高,值得推广应用。
Abstract：【Objective】To observe the clinical applications and effects of dexmedetomidine with propofol in painless colonoscopy. 【Methods】One hundred painless colonoscopy patients in our hospital were chosen as our study subjects and, according to the prescribed anesthesia program, were divided into the control group (n=50) and observation group (n=50). Patients in the control group were given propofol in conjunction with sufentanil, while the patients in the observation group were given dexmedetomidine with propofol. The anesthetic effects and safety were compared between the two groups.【Results】 The surgery time, recovery time, and hospital stay were significantly shorter in the observation group than in the control group (P<0.05). The propofol dosage given in the observation group was much less than the dosage given to the control group (P<0.05). The preoperative VAS scores, however, were not statistically different (P>0.05). At times 0.5h, 4h, and 8h postoperation, the VAS scores were significantly lower than in the control group (P<0.05). The rate of postoperative complications in the observation group was 8.0%, significantly lower than the 24.0% rate in the control group (P<0.05). 【Conclusion】 Compared with the use of propofol and sufentanil anesthesia in painless colonoscopy, propofol with dexmedetomidine anesthesia has a superior anesthetic effect and greater safety. Therefore it is worthy for wide applications.
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2016, Vol. 33 
