丁苯酞联合长春西汀治疗椎动脉优势型后循环缺血性眩晕的疗效及安全性分析

doi:10.3969/j.issn.1671-7171.2016.11.003

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摘要【目的】探讨丁苯酞联合长春西汀治疗椎动脉优势型后循环缺血性眩晕(PCIV)的有效性与安全性。【方法】将本院2014年1月至2015年10月收治的椎动脉优势型PCIV患者82例随机分为观察组及对照组两组,每组各41例。对照组应用长春西汀治疗,观察组应用丁苯酞联合长春西汀治疗,对比两组的临床疗效与副作用。【结果】观察组治愈率及总有效率(48.78%、92.68%)显著高于对照组(29.27%、80.49%);治疗后观察组的双侧椎动脉(LVA、RLA)、双侧大脑后动脉(LPCA、RPCA)及基底动脉(BA)的平均血流速度(Vm)显著高于对照组,而血液流变学指标(WBV、PV、PAI)显著低于对照组,差异均具有统计学意义(P<0.05)。【结论】丁苯酞联合长春西汀治疗PCIV疗效确切且用药安全,能够有效改善患者的血液流变学以及后循环缺血症状。

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	龚建祖
	程伟

关键词 ：苯丙酮类/治疗应用, 长春花生物碱类/治疗应用, 椎动脉, 眩晕/药物疗法, 血液流变学

Abstract：【Objective】To evaluate the efficacy and safety of butylphthalide combined with vinpocetine in the treatment of Posterior Circulation Ischemic Vertigo (PCIV) caused by the dominant vertebral artery.【Methods】Eighty-two cases of PCIV patients caused by the dominant vertebral artery were randomly divided into two groups: the control group (n=41) received vinpocetine therapy, and the experimental group (n=41) received butylphthalide combined with vinpocetine therapy. The clinical efficacy and side effects of the two groups were compared. 【Results】The cure rate and total effective rate of patients in the experimental group was 48.78% and 92.68%, respectively, and were significantly higher than for patients in the control group 29.27% and 80.49%, respectively. After treatment, the Vm of the bilateral vertebral artery (LVA, RVA), of the bilateral posterior cerebral artery (LPCA, RPCA), and of the basilar artery (BA) was significantly higher in the experimental group than in the control group. The hemorheology indexes (WBV, PV, and PAI) were significantly lower in the experimental group than in the control group, the differences between the two groups being statistically significant (P<0.05). 【Conclusion】It's safe and effective to use the combination of of butylphthalide and vinpocetine for treatment of PCIV caused by the dominant vertebral artery. The combined treatment can effectively improve the hemorheological and posterior circulation ischemic symptoms of patients.

Key words： Propiophenones/TU Vinca Alkaloids/TU Vertebral Artery Vertigo/DT Hemorheology

收稿日期: 2015-12-21

PACS:

R441.2

通讯作者: 程伟

引用本文:

龚建祖,程伟. 丁苯酞联合长春西汀治疗椎动脉优势型后循环缺血性眩晕的疗效及安全性分析[J]. 医学临床研究, 2016, 33(11): 2088-2091.
GONG Jian-zu, CHENG Wei. Clinical Efficacy and Safety of Butylphthalide Combined with Vinpocetine in the Treatment of Posterior Circulation Ischemic Vertigo Caused by the Dominant Vertebral Artery. JOURNAL OF CLINICAL RESEARCH, 2016, 33(11): 2088-2091.

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http://www.jcr.net.cn/CN/10.3969/j.issn.1671-7171.2016.11.003 或 http://www.jcr.net.cn/CN/Y2016/V33/I11/2088

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