Abstract：【Objective】 To investigate the protective effect of Trimetazidine on renal function in hypertensive patients with coronary heart disease. 【Methods】Eighty-six cases of hypertension with coronary heart disease were randomly divided into two groups, each of 43 cases. The control group was treated with routine therapy; while on the basis the control group, the observation group was treated with Trimetazidine. One course of treatment for 4weeks, 3 courses were intervened. Blood pressure, heart function and renal function and adverse reaction conditions were compared between the two groups before and after treatment.【Results】After treatment, DBP, SBP levels, LVEDD, LVESD, SCr one week after treatment, BUN, Cys C, hs-CRP and IL-6 levels in the two groups were significantly decreased than those before treatment while LVEF was significantly increased than that before treatment (P<0.05). 3 courses after the treatment, LVEDD, LVESD, LVEF, SCr one week after treatment, BUN, Cys C, hs-CRP, IL-6 and NO levels in the observation group were significantly improved than those in the control group (P<0.05). There were no significant differences in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Trimetazidine can significantly improve the cardiac function in hypertensive patients with coronary heart disease. It has also protective effect on renal function. This may be related to the drug functions of inflammation reduction and vascular endothelium improvement.
张艺平. 曲美他嗪对高血压伴冠心病患者肾功能的影响[J]. 医学临床研究, 2016, 33(10): 1960-1962.
ZHANG Yi-ping. Analysis of Protective Effect of Trimetazidine on Renal Function in Hypertensive Patients with Coronary Heart Disease. JOURNAL OF CLINICAL RESEARCH, 2016, 33(10): 1960-1962.
2016, Vol. 33 
