Abstract：【Objective】To investigate the changes of serum lipids in schizophrenic patients after withdrawal of risperidone treatment.【Methods】 Ninety-three cases of schizophrenia in our hospital were divided into 3 groups, 33 patients (group A) were not treated with antipsychotic drugs, 31 patients (group B) were treated with antipsychotic drugs, and 30 patients ceased antipsychotic treatment the risperidone for at least 3 months or more (group C). In addition, 32 healthy volunteers were selected as normal control group (group D).【Results】 The general clinical data and demographic data of all the patients were collected, and levels of body weight, waist and hip circumference, fasting serum three triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (apoA1) and apolipoprotein A2 (apoA2) were measured. BMI of the Group C was significantly higher than that of the Group A, the difference was statistically significant (P<0.05); The serum HDL level of the Group B and the Group C was significantly lower than that of A group, and the difference was statistically significant (P<0.05).【Conclusion】 The withdrawal of risperidone treatment in schizophrenic patients can not reverse the abnormal serum lipids in the short term.
蔡丽莉;李立群;李洋;陈泳康. 精神分裂症患者利培酮治疗停药后的血脂水平变化[J]. 医学临床研究, 2016, 33(10): 1935-1937.
CAI Li-li, LI Li-qun, LI Yang,et al. Changes of Serum Lipids in Schizophrenic Patients after Withdrawal of Risperidone Treatment. JOURNAL OF CLINICAL RESEARCH, 2016, 33(10): 1935-1937.
2016, Vol. 33 
