Abstract：【Objective】To discuss the positive rate of serum TPOAb and TGAb in pregnant women in Cangzhou area and its relationship with thyroid-stimulating hormone (TSH) level. 【Methods】A total of 786 cases of pregnant women were divided into T1, T2 and T3 groups according to gestational week. The serum levels of TSH, TPOAb and TGAb were determined by electrochemical immunoassay. According to whether TSH increased or not, they were divided into the TSH abnormal group and TSH normal group. Based on TPOAb and TGAb levels, they were divided into the TPOAb and TGAb double positive group, TPOAb positive group, TGAb positive group, and TPOAb and TGAb double negative group. 【Results】 In the T1, T2, T3 groups of pregnancy women, TPOAb positive rates were 9.95%, 11.07% and 11.22%, respectively, while TGAb positive rates were 8.14%, 9.09% and 8.65%, respectively. The positive rates of TPOAb and TGAb in the abnormal TSH group were higher than those in the TSH normal group, and the difference was statistically significant (P<0.05). The level of TSH in the TGAb and TPOAb double positive group was increased compared with that in the TPOAb positive group, TGAb positive group, and TPOAb and TGAb double negative group; the difference was statistically significant (P<0.05). 【Conclusion】The positive rates of TPOAb and TGAb were higher in the TSH abnormal group. The level of TSH in TGAb and TPOAb double positive group was increased. TPOAb, TGAb and TSH levels all can be used as indicators for assessing thyroid function in pregnant women.
魏粤晓;何雪娟;王吉云. 妊娠妇女甲状腺自身抗体与甲状腺功能的相关性分析[J]. 医学临床研究, 2016, 33(10): 1902-1904.
WEI Yue-xiao, HE Xue-juan, WANG Ji-yun. Correlation Analysis of Thyroid Autoantibodies and Thyroid Function in Pregnant Women. JOURNAL OF CLINICAL RESEARCH, 2016, 33(10): 1902-1904.
[1] Stagnaro-Green A, Abalovich M, Alexander E,et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum[J].Thyroid,2011, 21(10):1081-1125. [2] 中华医学会内分泌学分会,中华医学会围产医学分会.妊娠和产后甲状腺疾病诊治指南[J].中华围产医学杂志,2012,15(7):385-403. [3] Hollowell J G, Staehling N W,Flanders W D, et al. Serum TSH, T4 and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III) [J].Clin Endocrinol Metab,2002,87(2):489-499. [4] 江琳琳,黄佳,杨冬梓.抗甲状腺抗体与妊娠相关疾病关系的研究进展[J].中华妇产科杂志,2013,48(3):222-224. [5] 袁文玉.正常妊娠妇女甲状腺功能正常值探讨[D].昆明:昆明医科大学,2013. [6] 王丽霞,赵文娟,彭伟,等.妊娠早期妇女碘营养及甲状腺自身抗体与甲状腺功能减退症的关系[J].青岛大学医学院学报,2015,51(6):697-700. [7] 郭小楠,王琦,彭旭兰.某院1683例妊娠妇女甲状腺功能结果分析[J].检验医学与临床2015,11(21):3227-3229. [8] Demers LM, Spencer CA. Laboratory medicine practice guidelines: laboratory support for the diagnosis and monitoring of thyroid disease[J].Clinical endocrinology,2003, 58(2):138-140. [9] Behrooz HG,Tohidi M, Mehrabi Y,et al.Subclinical hypothyroidism in pregnancy: intellectual development of offspring[J].Hyroid,2011,21(10):1143-1147. [10] De Escobar GM,Ares S, Berbel P, et al. The chancing of maternal thyroid hormone in fetal brain development[J].Stemin Perinatol,2008,32(6):380-386. [11] 李彩霞,石学风,吴学香,等.孕妇妊娠期甲状腺激素水平变化及与TPOAb的相关性研究[J].重庆医学,2015,11(29):4089-4091.
2016, Vol. 33 
