FHIT和Survivin在鼻腔鼻窦内翻性乳头状瘤中的表达及其意义

doi:10.3969/j.issn.1671-7171.2016.10.002

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摘要【目的】检测分析鼻腔鼻窦内翻性乳头状瘤(SNIP)组织中抑癌基因脆性组氨酸三联体(FHIT)和Survivin表达水平及其意义。【方法】选取本院病理科2015年1～12月收集的58例SNIP组织标本(SNIP组)、鼻腔鼻窦鳞癌组织标本20例(鳞癌组)和正常鼻腔黏膜标本20例(正常组),采用免疫组化法观察三组标本的FHIT和Survivin蛋白表达水平,并对SNIP组患者的临床病理特征进行分析。【结果】SNIP组织中FHIT蛋白阳性表达率显著的低于正常组(P<0.05),高于鳞癌组(P<0.05);SNIP组织中的Survivin蛋白阳性表达率显著的高于正常组(P<0.05);SNIP组织中FHIT蛋白阳性表达率、Survivin蛋白阳性表达率与SNIP组的临床分期具有显著的相关性(P<0.05)。【结论】FHIT蛋白表达下调和Survivin蛋白表达上调对SNIP的发生发展具有重要作用。

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关键词 ：鼻肿瘤/病理学, 鼻窦肿瘤/病理学, 乳头状瘤/病理学, 基因, 肿瘤抑制, 染色体脆性, 组氨酸/遗传学

Abstract：【Objective】To detect and analyze the expression level and significance of fragile histidine three (FHIT) and Survivin in the tissues of sinonasal inverted papilloma (SNIP) .【Methods】 Fifty-eight cases of tissue samples of SNIP (SNIP group) , 20 cases of tissue samples of squamous cell carcinoma in the nasal cavity and nasal sinuses (Squamous Cell Carcinoma group) and 20 cases of normal nasal mucosa specimens (normal group) from Jan.- Dec.2015 in our hospital were collected. The expression levels of FHIT and Survivin in the three groups were observed by immunohistochemical method, and the clinical pathological characteristics of the patients with SNIP were analyzed.【Results】The positive expression rate of FHIT protein in the SNIP group was significantly lower than that in the normal group (P<0.05), and was higher than that in the squamous cell carcinoma group (P<0.05); the positive expression rate of Survivin protein in the SNIP group was significantly higher than that in the normal group (P<0.05); the positive expression rate of FHIT protein and the positive rate of Survivin protein in the SNIP group were significantly correlated with the clinical stage of the SNIP group (P<0.05).【Conclusion】Downregulation of FHIT protein expression and upregulation of Survivin protein play an important role in the occurrence and development of SNIP.

Key words： Nose Neoplasms/PA Paranasal Sinus Neoplasms/PA Papilloma/PA Genes, Tumor Suppressor Chromosome Fragility Histidine/GE

收稿日期: 2016-03-24

PACS:

R739.62

基金资助:陕西省科学技术研究发展计划(2013K12-12-04)

引用本文:

景阳;杨晓蓉;王宇娟;张文;刘晖;王敏. FHIT和Survivin在鼻腔鼻窦内翻性乳头状瘤中的表达及其意义[J]. 医学临床研究, 2016, 33(10): 1876-1879.
JING Yang, YANG Xiao-rong, WANG Yu-juan,et al. Expression and Significance of FHIT and Survivin in Tissues of Sinonasal Inverted Papilloma. JOURNAL OF CLINICAL RESEARCH, 2016, 33(10): 1876-1879.

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http://www.jcr.net.cn/CN/10.3969/j.issn.1671-7171.2016.10.002 或 http://www.jcr.net.cn/CN/Y2016/V33/I10/1876

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