Abstract：【Objective】To investigate the independent risk factors of neonatal cerebrospinal fluid abnormalities in febrile infants. 【Methods】 According to the result of cerebrospinal fluid examination, 325 febrile infants were divided into an observation group of infants with abnormal indexes (n=79) and a control group of patients with normal indexes (n=246). The clinical data of neonatal indicators of patients in the two groups were collected and analyzed using Logistic regression analysis. 【Results】(1) Single factor analysis showed that amniotic fluid turbidity, method of childbirth, sex, Apgar(Appearance,Pluse,Grimace,Activity,Respiration) score, basic diseases, nervous system symptoms, the result of urine routine, stool routine, and blood culture showed no statistically significance difference between the two groups (P>0.05). However, the difference between the two groups of children in premature rupture of membranes, birth weight, highest temperature, time of fever occurring , duration of fever, and infection type were statistically significant (P<0.05). Premature rupture of membranes. (2) Logistic regression analysis showed that premature rupture of membranes, highest temperature ≥38.5 ℃, age at time of fever is 14 days or less, heating duration ≥ 3 d, and bacterial infection are independent risk factors for neonatal cerebrospinal fluid abnormalities (P<0.05). Birth weight 2.5 Kg or less is not an independent risk factor for neonatal cerebrospinal fluid abnormalities (P>0.05). 【Conclusion】 For febrile newborns, when premature rupture of membranes occurs during the mother's pregnancy, age at time of fever is 14 days or less,highest temperature is ≥38.5℃, fever duration ≥3 d, or diagnosis of bacterial infection, the clinical doctors should give cerebrospinal fluid examination as soon as possible for the early diagnosis and treatment of intracranial infection.
2016, Vol. 33 
