Abstract:【Objective】To investigate the therapeutic effect of closed reduction and minimally invasive percutaneous plate osteosynthesis (MIPPO) in the treatment of proximal humeral fractures.【Methods】Sixty cases of proximal humeral fractures were randomly divided into two groups, 30 cases in each group. The observation group was treated with MIPPO; the control group was treated with routine operation incision and internal fixation. The operation time, blood loss, incision size, and Xray fracture reduction in 3 months after operation,incidence of complications 12 months after operation and the Neer score of shoulder joint were compared between the two groups.【Results】The operation time of the observation group was (50.6±9.7) min, which was significantly shorter than that of the control group (71.9±9.2) min; The amount of bleeding in the observation group was (149.7±37.1) mL, which was significantly less than that of the control group (245.4±46.1) mL; The incision diameter of the observation group was (7.8±0.7) cm, significantly smaller than that of the control group (15.2±1.4) cm. The postoperative excellent rate of observation group was 93.3% (28/30), significantly higher than the control group 80% (24/30), the difference was statistically significant (mean P<0.05). In the observation group, 12 months after surgery, no necrosis of the humeral head and axillary nerve injury were found; in the control group, no necrosis of the humeral head was found in 12 months after operation, but there was only 1 case with axillary nerve injury, and all the fractures healed.【Conclusion】Compared with the conventional open reduction and internal fixation, MIPPO treatment of proximal humerus fractures has the advantages of shorter operation time, less blood loss, smaller incision, better reduction and fewer complications. It is worth of clinical application.