Abstract：【Objective】To investigate the correlation between serum uric acid (UA) and thyroid function in patients with primary hyperthyroidism.【Methods】Sixtyone cases of primary hyperthyroidism were collected, and were divided into hyperuricemia (HUA) group and normal uric acid (NUA) group according to the blood UA level (male >420 mol / L, female > 360μmol／L). In addition, healthy physical examination population of the same age and gender matched were collected as a healthy control group. The following were detected and compared in the three groups including the thyroid function indicators: free three iodine thyroid gland (FT3), free thyroid hormone (FT4), thyroid stimulating hormone (TSH) level), Fasting blood glucose (FBS); the renal function: blood urea nitrogen (BUN), creatinine (Cr), UA; the liver function: alanine aminotransferase (ALT) and aspartate aminotransferase (AST); the blood lipids: three glycerol (TG), cholesterol (TC), high density lipoprotein (HDLC), low density lipoprotein (LDLC) . The correlation between UA and thyroid function was analyzed.【Results】FT3 and FT4 in the NUA group were significantly higher than the control group (P<0.01), while the TC, HDLC, LDLC, TSH were significantly lower than the control group (P<0.01), but there was no significant difference between the two groups in FBS, AST, TG, BUN, Cr , UA (P>0.05). Compared with NUA group, BUN, UA, Cr, FT3, FT4 of the HUA group were significantly increased (P<0.05), TSH level was significantly decreased, and the difference was statistically significant (P<0.05); there was no significant difference in FBS, ALT, AST, TG, TC, HDLC, LDLC in the two groups (P>0.05). UA was positively correlated with FT3 and FT4 (P<0.05), and was negatively correlated with TSH (P<0.05), Serum Cr was negatively correlated with FT3 and FT4 (P<0.05). 【Conclusion】Patients with primary hyperthyroidism can be easily combined with blood UA elevation. The level of serum UA is closely related to the level of thyroid hormone of patients.
王霞 张弛. null[J]. 医学临床研究, 2016, 33(9): 1668-1670.
WANG Xia，ZHANG Chi. Study on the Correlation of Serum Uric Acid in Patients with Primary Hyperthyroidism. JOURNAL OF CLINICAL RESEARCH, 2016, 33(9): 1668-1670.
2016, Vol. 33 
