Abstract：【Objective】To investigate the mechanism of hydrogen sulfide delayed preconditioning on myocardial ischemia reperfusion injury in rats. 【Methods】Three groups (n=10 animals/group) of SpragueDawley male rats were studied: group S consisted of control rats that received no treatment, Group IR consisted of rats treated with NS (1.0 ml/kg iv) 24 h before ischemia, and Group H consisted of rats treated with NaHS (0.05 mg/kg) 24 h before ischemia. Group IR and H were subjected to ischemia by 30 min of coronary artery occlusion followed by 2 h of reperfusion. At the end of reperfusion, the plasma concentration of IL6 and IL10 were measured. The peroxisome proliferatoractivated receptor γ (PPARγ) was measured by Western blotting. 【Results】Compared with Group S, Group H and Group IR had higher levels of IL6 and IL10 (P<0.05). Compared with Group IR, Group H had lower levels of IL6 and higher levels of IL10 (P<0.05). Compared with Group S, Group H and Group IR had lower PPARγ protein expression in myocardium (P<0.05).Compared with Group IR, Group H had higher levels of PPARγ protein expression (P<0.05).【Conclusion】The hydrogen sulfide delayed preconditioning attenuates myocardial IR injury possibly through upregulating PPARγ expression in rats.
蒋海涛1 冉珂2**李志坚2 常业恬2. 硫化氢延迟预处理抑制大鼠心肌损伤的机制研究[J]. 医学临床研究, 2016, 33(8): 1484-1488.
JIANG Haitao,RAN Ke,LI Zhijian, et al. An Investigation on the Mechanism of Hydrogen SulfideInduced Delayed Preconditioning on Myocardial Ischemia Reperfusion Injury in Rats. JOURNAL OF CLINICAL RESEARCH, 2016, 33(8): 1484-1488.
2016, Vol. 33 
