Analysis of the Correlation between Vascular Endothelial Dysfunction and Coronary Heart Disease in Elderly Patients with Obstructive Sleep Apnea Syndrome
Abstract：【Objective】To analyze the correlation between vascular endothelial dysfunction and coronary heart disease (CHD) in elderly patients with obstructive sleep apnea syndrome (OSAS). 【Methods】
A total of 32 cases of patients with OSAS in our hospital from February 2014 to August 2015 were selected as the OSAS group. Another 35 cases of patients with CHD and OSAS in the same time period at our hospital were selected as the OSAS and CHD group. Apneahypopnea index (AHI) and oxygen desaturation index (ODI) of patients in both groups were detected. Meanwhile, plasma endothelin (ET), nitric oxide (NO) and NO/ET ratio were compared between patients of the two groups, and the correlation between OSAS patients with vascular endothelial dysfunction and coronary heart disease were analyzed. 【Results】Compared to OSAS and CHD group, ODI, AHI, the lowest SpO2, and mean SpO2 were significantly decreased in the OSAS group; the difference had statistical significance (P<0.05). ET and NO/ET also decreased significantly in the OSAS group compared to the OSAS and CHD group. In contrast, NO levels significantly increase in the OSAS group compared to the OSAS and CHD group; the difference was statistically significant (P<0.05). 【Conclusion】Obstructive sleep apnea syndrome complicated with coronary heart disease in elderly patients has obvious effect on endothelial dysfunction and vascular endothelial. Therefore, active prevention and treatment of vascular endothelial dysfunction can improve the prognosis of the patients with OSAS and CHD.
2016, Vol. 33 
