Abstract:【Objective】To explore the clinical outcomes of application of absorbable haemostat (S100) during internal fixation of clavicle fractures. 【Methods】From February 2014 to March 2015, 52 patients with different types of clavicle fractures were subjected to surgical treatment. They were 38 men and 14 women, with a mean age of 44.5 years (from 22 to 78 years). They received internal fixation of clavicle fractures and were divided into the experimental group, which adopted S100 absorbable haemostat and regular hemostatic measures during the surgeries, and the control group, which adopted regular hemostatic measures. By random division each group had 26 cases. The two groups were observed for 2 weeks for bleeding volume, bacterial culture of secretion, and the recovery of the wound. After leaving the hospital, the patients got back to outpatient department for checking recovery of the wound and acquired Constant score of shoulder joint function test every 4 weeks until the 12th week after operations. The two groups were not significantly different in general clinical data (P>0.05). 【Results】The average drainage volume of the experimental group (8.3±2.6 mL) was significant less than that of the control group ( 20.2±4.3 mL)(P<0.05). Two patients (7.69%) of experimental group experienced congestion, swelling, and effusion of the wound in the surgical area, while nine patients(34.6%) had similar experiences in control group; the difference between the two was significant (P<0.05). No cases of infection were found in the experimental group but one was found in the control group, and staphylococcus aureus was cultured out of the secretion. According to the outpatient checkingin after 12 weeks, there was no significant difference between the two groups in situation of soft tissue or in the goodexcellent rates of Constant score (96.2% versus 92.3%) (P>0.05). One patient of the experimental group found continual pain in the operated shoulder and two patients found aching and stiff neckshoulder 3 months after surgery. 【Conclusion】Application of absorbable haemostat (S100) during internal fixation of clavicle fractures could reduce surgical bleeding, cause no infection, and speed up the recovery of incision and soft tissue, leading to satisfactory results.