Abstract:【Objective】 To discuss the effect of sliding bone graft combined with locking compression plate (LCP)internal fixation for the treatment of nonunion after femoral fracture surgery.【Methods】Forty seven cases with nonunion of femoral fractures treated in the Department of Orthopedics of our hospital were selected. Upon the sliding bone graft combined with LCP internal fixation, the functional recovery and postoperative prognosis of patients were evaluated. 【Results】Forty seven patients were successfully operated: the average length of incision (17.4±10.8) cm, the operative time (152.6±19.4) min, blood loss (181.5±58.0) mL, postoperative drainage (139.4 ± 47.3) mL;3 patients were out of followed up, 1 patient occurred plate and screw loosening, 2 patients recurred nonunion due to infection. After internal fixation removal and infection control, the patients were treated with the inlay external fixation device for 7 months and the bone was healed duly. The healing time of fracture was 7.1 to 9.8 (8.2±1.4) months in the remaining 41 cases. The patients were followed up from 3.2 to 14 (11.6±2.9) months. The HSS scores of knee joint after 6 months and last followup and the Lysholm scores were significantly improved and compared with the preoperative (P<0.05).【Conclusion】 The effect of sliding bone graft combined with LCP fixation in the treatment of postoperative nonunion after femoral fracture is reliable with good recovery of the knee joint function and less complications. It is worthy of clinical application.