马骨续筋胶囊治疗青壮年股骨颈骨折的早期疗效观察

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摘要【目的】探讨马骨续筋胶囊治疗青壮年股骨颈骨折的早期临床疗效。【方法】选取2014年2月至2015年2月在本院接受治疗的青年股骨颈骨折患者55例，采用随机数表法随机分为两组，对照组27例，采用闭合复位空心钉固定等常规治疗；观察组28例，在常规治疗的基础上，采用口服马骨续筋胶囊治疗，治疗42 d后对两组患者情况根据临床记录进行疗效评定，比较两组d14、d21、d42消肿情况、主观疼痛消失时间、骨痂生长情况及血钙下降水平。【结果】根据症状轻重程度计分法为患者进行评分，结果显示观察组d21、 d42评分为0.902±0.302、0.082±0.324，显著低于对照组1.105±0.213、0.113±0.34，其差异有统计学意义（P<0.05）；观察组患者主观疼痛消失平均时间为（6.056±1.779）d，显著低于对照组（8.035±1.093）d，其差异有统计学意义（P＜0.05）；观察组在服用马骨续筋胶囊的d14、d21、d42骨痂生长情况评分为0.664±0.021、1.965±0.121、2.983±0.122，显著高于对照组0.521±0.015、1.654±0.123、2.750±0.111，其差异有统计学意义（P＜0.05）；观察组在服用马骨续筋胶囊的d14、d21、d42血钙浓度分别为2.562 mmol/L、2.325 mmol/L、2.176 mmol/L；对照组为2.563 mmol/L、2.545 mmol/L、2.400 mmol/L，两组患者血钙浓度前14 d均下降，但比较差异无统计学意义（P＞0.05），观察组d21、d42血钙浓度较对照组下降速度加快，差异有统计学意义（P＞0.05）。【结论】马骨续筋胶囊能缩短患者的主观疼痛时间,促进患处骨痂的生长、活血化瘀，消肿效果明显，促进股骨颈骨折愈合指标的改善。

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关键词 ：胶囊, 股骨颈骨折/中药疗法, 治疗结果

Abstract：【Objective】To observe the early clinical effect of Maguxujin capsule on the treatment of femoral neck fracture in young adults. 【Methods】 Fiftyfive cases of young adult femoral neck fracture patients in our hospital from February 2014 to February 2015 were selected and randomly divided into the treatment group (28 cases) and control group (27 cases). The control group were given with conventional therapy(Closed reduction and hollow screw fixation); the treatment group were treaded with Maguxujin capsule on the basis of routine treatment. 42 days after treatment, the time of subjective pain disappearance and swelling , callus growth and the serum calcium decreased level of the two groups on d14, d21, d42 were evaluated and compared. 【Results】Patients were scored in accordance to the severity of symptoms method . The results showed that in the observed group d21、d42 score was 0.902 ± 0.302, 0.082 ±0.324, which were significantly lower than those of the control group 1.105 ± 0.213, 0.113 ± 0.34, the difference had statistical significance (P<0.05)；In the observation group, the subjective pain disappearance time averaged (6.056 ±1.779) d ,which was significantly lower than that in control group (8.035 ± 1.093) d, the difference had statistical significance (P<0.05). In the observation group, on d14, d21, d42 after taking Maguxujin capsules, callus growth score was 0.664 ± 0.021, 196.5 ±0.121, 2.983 ±0.122, which were significantly higher than those of the control group 0.521 ± 0.015, 1.654 ±0.123, 275 ± 0.111, the difference had statistical significance (P<0.05);In the observation group, on d14, d21, d42 after taking Maguxujin capsules, the serum calcium concentration were 2.562 mmol / L, 2.325 mmol, 2.176 mmol/L respectively;while in the control group, they were 2.563 mmol/L、2.545 mmol/L、2.400 mmol/L, the serum calcium level of the two groups of patients were decreased during the previous14 days, but difference had no statistical significance (P> 0.05); the serum calcium level of d21, d42 in the observation group decreased faster than that of the control group, the difference was statistically significant (P>0.05).【Conclusion】 Maguxujin capsule can shorten the patient's time of subjective pain, promote the lesion of bone callus growth, active blood circulation and remove blood stasis with sound detumescence effect. It is expected to improve femoral neck fracture healing

Key words： CAPSULES△ Femoral Neck Fractures/ZD Treatment Outcome

收稿日期: 2016-02-19

引用本文:

邵明星王峰石晶刘国强潘浩吴文元王海章. 马骨续筋胶囊治疗青壮年股骨颈骨折的早期疗效观察[J]. 医学临床研究, 2016, 33(5): 873-875.
SHAO Mingxing，WANG Feng，SHI Jing,et al. Early Clinical Observation on Effect of the Treatment of Femoral Neck Fracture in Young Adults with Maguxujin Capsule. JOURNAL OF CLINICAL RESEARCH, 2016, 33(5): 873-875.

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http://www.jcr.net.cn/CN/ 或 http://www.jcr.net.cn/CN/Y2016/V33/I5/873