Abstract：【Objective】To investigate the composition and drug resistance of pathogens in lower respiratory tract in patients with chronic obstructive pulmonary disease (COPD) with invasive mechanical ventilation. 【Methods】 The 380 patients with COPD who were treated with invasive mechanical ventilation in our hospital from January 2011 to December 2014 were selected as the study subjects. The lower respiratory tract secretions of patients were collected and cultured, The pathogenic bacteria composition ratio and main sensitivity results of pathogenic bacteria drug were analyzed.
【Results】 In 380 cases of lower respiratory tract secretions, 342 strains of pathogenic bacteria were detected, including 223 gram negative bacteria (65.20%), 92 strains of gram positive bacteria (26.90%) and 27 strains of fungi (7.89%). Among the gram negative bacteria, 53 strains of Acinetobacter Bauman (23.77 %), 48 strains of Stenotrophomonas maltophilia (21.52%), 42 strains of verdigris pseudomonas (18.83%) and 34 strains of Klebsiella pneumonia (15.25%). Among the gram positive bacteria, 31 strains of Staphylococcus aureus (9.06%), 24 strains of Streptococcus pneumonia (7.02%), 16 strains of Staphylococcus haemolyticus (4.68%) and 14 strains of Staphylococcus epidermidis (4.09%). 11 strains of Candida albicans (3.22%), 8 strains of Tropical Candida (2.34%) and 6 strains of Aspergillus (1.75%). Bauman Acinetobacter was sensitive to gentamicin, Amikacin, tobramycin and minocycline. Stenotrophomonas maltophilia was sensitive to ciprofloxacin and levofloxacin. Pseudomonas aeruginosa was sensitive to ciprofloxacin, levofloxacin and tobramycin and minocycline. Klebsiella pneumoniae was sensitive to imipenem, Amikacin, tobramycin, ciprofloxacin and levofloxacin. The gram positive bacteria were sensitive to vancomycin and teicoplanin, rifampicin, linezolid and sulfamethoxazole compound. Except for Aspergillus, Candida albicans and Tropical Candida were more sensitive to antifungal agents. 【Conclusion】 The infection rate and drug resistance rate of COPD are high. To understand the distribution and drug resistance of pathogenic bacteria in our hospital can provide the basis for clinical rational use of antibiotics, reduce drug resistance rate and improve the cure rate and shorten the treatment time.
姚剑坤. COPD有创机械通气患者下呼吸道病原学及耐药性分析[J]. 医学临床研究, 2016, 33(5): 865-869.
YAO Jiankun. Analysis of Pathogenic and Drug Resistance of Lower Respiratory Tract in COPD Patients Underwent Invasive Mechanical Ventilation. JOURNAL OF CLINICAL RESEARCH, 2016, 33(5): 865-869.
2016, Vol. 33 
