Abstract:【Objective】To discuss the clinical evaluation on the correlation between the weight and fetal subcutaneous soft tissue thickness and liver length . 【Methods】1713 cases of normal fetuses with gestational age from13 to 40 weeks were divided into six groups according to gestational age: group A (13 ~ 16 weeks); group B (17 ~ 20 weeks); group C (21 ~ 24 weeks); group D (25 ~ 28 weeks); Group E (29 to 32 weeks); Group F (33 to 36 weeks); group G (37 ~ 40 weeks). 4D ultrasound was used to measure fetal biparietal diameter, head circumference, abdominal circumference, femur length, humerus length, and to estimate the EFW. Measurement of fetal neck skin thickness (NF), cheektocheek diameter (CCD), abdominal soft tissue thickness (ASTT), humeral soft tissue thickness (HSTT), femoral soft tissue thickness (FSTT) subcutaneous soft tissue thickness and liver length (LL)were simultaneously conducted, The correlation between the indicators and EFW were analyzed . 【Results】NF, CCD, ASTT, HSTT subcutaneous soft tissue thickness and LL and EFW showed significant positive correlation (r=0.53, 0.66, 0.60, 0.68, 0.71, 0.88,P<0.05) and NF, CCD, ASTT, HSTT and LL were positively related with gestational age(r=0.72, 0.71, 0.68,0.78, 0.81, 0.82,P<0.05)【Conclusion】 NF, CCD, ASTT, HSTT subcutaneous soft tissue thickness and LL and EFW show significant positive correlation. Fourdimensional color Doppler ultrasound measurement of NF, CCD,ASTT, HSTT, FSTT, LL and EFW are relatively accurate. The method is simple and convenient, and is worth to be popularized in clinical application.