Abstract：【Objective】To evaluate the effects of dexmedetomidine on hemodynamics and recovery quality for patients undergoing intracranial aneurysms embolism under general anesthesia. 【Methods】40 adult patients with ASA class Ⅰ~Ⅱ for aneurysm embolization were divided randomly into two groups (n=20). All patients were anesthetized with the same scheme of induction and maintenance. The patients in group treated with dexmedetomidine received intravenously bolus dexmedetomidine 0.6 g/（kg•10min） 15 min prior to anesthesia followed by 0.4 g/（kg•h） during the operation. The patients in the saline group received the same dose of saline. HR and MAP were recorded preinfusion, 10 min after infusion, postintubation, end of the surgery, preextubation, immediately after extubation, 5 min after, and 10 min after. Waking time, extubation time, restless and cough score were observed and recorded. Sedation scores were evaluated and recorded with the Ramsay score after 10 min of extubation. 【Results】The operation time, waking, and extubation time were no different between both groups (P>0.05). MAP and HR were significantly lower in patients of group dexmedetomidine than patients in group saline at the time of intubation and preextubation, extubation and 5 min after extubation (P< 0.05). Ramsay sedation scores were higher in patients of the dexmedetomidine group than in patients of group saline at the time of 10 min after extubation, and cough score, agitation score were significantly lower in patients of group dexmedetomidine than patients of group saline (P<0.05). 【Conclusion】It is helpful to stabilize hemodynamics and improve recovery quality when the patients undergoing intracranial aneurysms embolism are administered dexmeditomidine intravenously with bolus 0.6 g/（kg•10min） and followed by 0.4 g/（kg•h）.
2016, Vol. 33 
