Abstract：【Objective】To investigate the clinical performance of rhGMCSF Gargles combined with Ribavirin Spray in treatment of children with herpetic angina. 【Methods】150 children in our hospital from May 2013 to March 2014 with herpetic angina were chosen for this study in the First Clinical College affiliated to Harbin Medical University. The children were divided into two groupsthe control group and the observation group. Both groups were treated with Ribavirin Spray after each meal and before sleep, but the observation group was treated with rhGMCSF in addition to the Ribavirin spray. Success in this experiment was defined by three categories: clinical improvements, cure of herpes, and lack of ulceration. In addition, the two groups were compared with the efficiency, time to cure, and length of stay. 【Results】The total success rate in the experimental group was 96%, which was significantly higher than the control group's with 84% success rate, the difference was statistically significant (P<0.05). The time it took to cure herpes was 1.5 days shorter in experimental group than in control group, and the fever last time in experimental group was 8 hours less than in control group. The length of stay was 1 day shorter in the experimental group than the control group. The results are statistically significantly.【Conclusion】The clinical application of rhGMCSF Gargles combined with Ribavirin Spray in treating pediatric oral herpes leads to a quicker and superior improvement in children with herpetic angina.
张鸿彦 张国利 赵文成 孙禄 徐燕霞. rhGMCSF含漱液联合巴韦林气雾剂治疗儿童疱疹性咽峡炎疗效观察[J]. 医学临床研究, 2016, 33(1): 26-32.
ZHANG Hongyan，ZHANG Guoli，ZHAO Wencheng,et al. Clinical Performance of rhGMCSF Gargles combined with Ribavirin Spray in the Treatment of Children with Herpetic Angina. JOURNAL OF CLINICAL RESEARCH, 2016, 33(1): 26-32.
2016, Vol. 33 
