Abstract：【Objective】To investigate the prognostic value of Doppler sonography for the ventricular septal defect(VSD) in the 1924 weeks gestation. 【Methods】 A singlecentre prospective observational study was conducted．The pregnant women who underwent the prenatal examination in our hospital from December 2012 to January 2015 were enrolled and were divided into the VSD group(217 cases) and the control group (3535 cases) according to the prenatal ultrasound diagnosis examination at any time and followup within one year of diagnosis results. Fetal hemodynamics of the two groups of pregnant 19 to 24 weeks were recorded and compared : umbilical artery pulsatility index (UAPI) ; middle cerebral artery pulsatility index (MCAPI), middle cerebral artery resistance index( MCARI); splenic artery pulsatility index PI (SPAPI), splenic artery resistance index (SPA RI), splenic artery peak systolic velocity (SpAPSV); brain / umbilical pulsatility index ratio (MCA/UAPI )and brain / umbilical vascular resistance index ratio (MCA/UARI). 【Results】 Fetal UAPI (1.31 ± 0.54), UARI (0.77±0.33) of the VSD group were significantly higher than those the control group (1.09 ±0.33 and 0.68 ± 0.23) (P<0.05), MCAPI (1.48 ± 0.24), MCA/UAPI (1.12 ± 0.29), MCA/UARI (0.99 ±0.18) were significantly lower than those of the control group (1.61 ±0.33, 1.38 ± 0.33 and 1.11 ± 0.20) (P<0.05), but no statistically significant difference exist in MCARI, SpA, PI, SpA, RI, SpAPSV between the two groups (P>0.05). Logistic regression analysis showed that the increase of UAPI (OR=6.314, 95% CI: 240 ~ 24.803) and the decrease of MCAPI (OR=5.887, 95% CI: 1.078 to 13.637) and MCA/UAPI (OR=11.283, 95% CI: 1.597 ~ 106.442) were independent risk factors for prediction of VSD.【Conclusion】At 19 to 24 weeks, the increase of UAPI and the decrease MCAPI and MCA/UAPI are useful marker to predict the occurrence of fetal VSD.
2016, Vol. 33 
