Abstract：【Objective】To compare and analyze the clinical effect of allogeneic frozen bone graft versus autogenous bone graft in the treatment of large bone defects, and to evaluate the safety and efficacy of allogeneic frozen bone graft. 【Methods】From July 2009 to July 2014, 60 cases of large bone defects treated in our hospital were selected as study objects. They were randomly divided into observation group and control group by random number table method. The observation group received allogeneic frozen bone graft treatment, the control group received autogenous bone graft treatment. The efficacy difference and complication between the two groups were compared and analyzed . 【Results】The success rates in the observation group were 93.3%, and 96.7% in the control group, but the difference was not statistically significant (P>0.05). The bone healing time in the observation group was（12.3±4.2）months, and（10.7±5.3）months in control group, but the difference was not statistically significant (P>0.05); The drainage 48h postoperation in the observation group were （262.6±38.9）mL, and in control group were（249.4±49.2）mL, the control group was lower than the observation group, but the difference was not statistically significant (P>0.05). There were no significant differences between the observation group and control group in the cases of rejection, infection, fever, wound exudate, delayed and healing (P>0.05). 【Conclusion】Allogeneic frozen bone has a similar effect and safety to autogenous bone graft, but will not cause secondary trauma, easily obtained, is worthy of learning to use.
康献刚 赵智远 吴旭芝 沈庆欣 武密山. 同种异体冷冻骨移植治疗大段骨缺损的安全性及有效性分析[J]. 医学临床研究, 2016, 33(1): 1-4.
KANG Xiangang，ZHAO Zhiyuan，WU Xuzhi,et al. Safety and Efficacy Analysis of Allogeneic Frozen Bone Graft in the Treatment of Large Bone Defects. JOURNAL OF CLINICAL RESEARCH, 2016, 33(1): 1-4.
