Abstract：【Objective】To explore the efficacy and security of oral S1 with synchronous radiotherapy plus chemotherapy for locally advanced pancreatic cancer. 【Methods】: 28 patients with locally advanced pancreatic cancer confirmed by pathology or in accordance with the criteria of clinical diagnosis were collected. Radiotherapy plan was: 10MVX, tumor gross target volume (GTV) were tumor tissues and metastatic lymph nodes, the radiation dose (DT) was 50 Gy/25 times (5 weeks), 1 time / day, plus S1 at a dose of 40～60 mg/d, 1 time / day (according to the patient's body surface area calculation: <1.25 m2, 40 mg/d;≥1.25~1.5 m2, 50 mg/d; ≥1.5 m2, 60 d mg/)during radiotherapy(d1~35); 2 weeks after the end of chemoradiotherapy, the single chemotherapy S1 was administered at a dose of 80~120 mg/d,2 times administered (according to the patient's body surface area calculation: <1.25 m2, 80 mg/d;≥1.25~1.5 m2, 100 mg/d; ≥1.5 m2 120 mg/d), a total of 14 days followed by 1week rest as a treatment cycle. Oral chemotherapy were taken until disease progressed or intolerance to its toxicity occurred. Therapeutic effect evaluation standard was used to evaluate the curative effect of solid tumor response. Toxic and side effects were evaluated by conventional toxicity criteria of the National Cancer Institute ,USA.【Results】Twentysix patients(26/28) finished the whole treatment upto progression .The tumor response rate （CR+PR）was 38.4%（10/26）and tumor control rate （CR+PR+SD）was 80.8%（21/26）.The clinical benefit rate was 53.9%（14/26）. Followup suggested the median progression free survival and median survival time were 6.3 months and 12.8 months. 1 year overall survival rate was 46.3%.The most common toxic effects were hematologic toxicity (12 degree),the major non hematologic toxicities were nausea and anorexia. 【Conclusion】Oral S1 with synchronous radiotherapy plus chemotherapy was a feasible and effective treatment with mild toxicity for locally advanced pancreatic cancer. The longterm results and toxicity still need further observe.
2015, Vol. 32 
