Abstract：【Objective】
To explore how maintenance hemodialysis (HD) of patients with zinc (zinc alpha 2glycoprotein alpha 2 glycoprotein, ZAG) affects the level change of metabolism in patients with HD. 【Methods】
Fifty cases undergoing the blood purification treatment of maintenance hemodialysis patients at our hospital were chosen as subjects of study, while clinic examination established 30 healthy cases to serve as the control group. Application of the ELISA detection method was used to detect ZAG, leptin and adiponectin levels, and detection of clinical and biochemical data was used to detect blood urea nitrogen (BUN), creatinine (Cr), fasting blood glucose (FBG), fasting insulin (Fins), total cholesterol (TC), free fatty acid (FFA), high density lipoprotein (HDL) and low density lipoprotein (LDL), and insulin resistance index. Patient sex, age, dialysis duration, and body mass index (BMI) data were also collected. 【Results】 Serum creatinine, BUN, and GFR difference was statistically significant (P< 0.01), but there was no significant difference in FBG, Fins, and HOMRIR between the groups (P>0.05). TG, LDL, FFA, adiponectin, and leptin between the two groups were statistically different (P<0.05), but the difference in TC and HDL was not (P>0.05). ZAG was positively correlated to LP, ADPN, HOMRIR and inversely correlated to CRP, GFR, BMI and HDL. Furthermore, multiple regression analysis showed that ZAG was very closely related with HDL and ADPN.【Conclusion】In maintenance hemodialysis patients, ZAG levels are higher than that in the normal group. ZAG affects lipid and glucose metabolism through LP and ADPN, which in turn reduces BMI and lipid accumulation.
2015, Vol. 32 
