Abstract:【Objective】To investigate the correlation between homocysteine (Hcy), uric acid (UA) level and different gender patients with unstable angina pectoris (UAP). 【Methods】276 cases of patients with UAP in our hospital were divided into male UAP group (154 cases) and female UAP group (122 cases). Another 160 cases of people who received coronary angiogram inspection and were diagnosed without coronary heart disease were used as control group, including male control group (82 cases) and female control group (78 cases). The general data were analyzed. 【Results】There were significant difference in smoking, high density lipoprotein cholesterol (HDL), Hcy, vitamin B12 (Vit B12) and folic acid (FA) between male UAP group and male control group (P<0.05 or P<0.01). There were significant difference in high blood pressure, diabetes, UA, Hcy, Vit B12 and FA between female UAP group and female control group (P<0.05 or P<0.01). Logistic regression analysis showed that smoking, high blood pressure, HDL, Hcy and Vit B12 were independent risk factors of male UAP (P<0.05 or P<0.01); high blood pressure, UA, Hcy and Vit B12were independent risk factors of female UAP (P<0.05 or P<0.01). 【Conclusion】UA and Hcy are independent risk factors of female UAP; Hcy is independent risk factor of male UAP, not for UA.