Abstract：【Objective】To investigate the dynamic changes of serum hepatitis B surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) levels for the prediction of the therapeutic effect of interferon on HBeAg positive chronic hepatitis B. 【Methods】The clinical data of 47 patients with chronic hepatitis B treated by(PEGIFNα2a in the Public Health Center of Shanghai were analyzed retrospectively. Treatment:48～72 weeks, once/week,180μg,24 weeks of followup after treatment. According to the criteria for sustained viral response (SVR), patients were divided into the SVR group and the non SVR group. The levels of serum HBsAg and HBeAg of pretreatment, 12 weeks and 24 weeks post treatment were detected respectively, and the dynamic changes of the related indexes of the two groups were observed.【Results】In the twelfth week of treatment and 24week followup ,the level of serum HBeAg in patients of the SVR group was significantly lower than that in the non SVR group, the difference was statistically significant(P<0.05); In twentyfourth week of followup, the level of serum HBsAg of the SVR group was significantly lower than that in the non SVR group, the difference was statistically significant(P<0.05). The decreasing rate of serum HBeAg and HBsAg levels in the SVR group were significantly higher than those in the non SVR group, the difference was statistically significant (P<0.05). ROC curve analysis showed that the HBeAg level had the best predictive value at 24th week.【Conclusion】Both HBsAg and HBeAg have good predictive value on the efficacy of interferon, while HBeAg is better than HBsAg.
肖宏 孙洪清 杨斐 李菊花. 定量检测HBsAg和HBeAg在干扰素治疗HBeAg阳性慢性乙肝疗效中的预测价值[J]. 医学临床研究, 2015, 32(9): 1674-1676.
XIAO Hong SUN Hongqing YANG Fei et al. Prediction Value of HBsAg and HBeAg in the Therapeutic Effect of Interferon on HBeAg Positive Chronic Hepatitis B. JOURNAL OF CLINICAL RESEARCH, 2015, 32(9): 1674-1676.
2015, Vol. 32 
