Abstract：【Objective】 To explore the significance and characteristics of four tumor markers like CEA, NSE, CYF211 and CA125 in clinical differentiation and diagnosis of patients with tuberculosis. 【Methods】145 cases of patients with tuberculosis confirmed by clinic were collected, and 60 cases of patients with pulmonary tumor plus 60 cases of healthy control group were also collected. The serum content of the four tumor markers like CEA, NSE, CYF211 and CA125 of the three groups were detected by electrochemical fluorescence immunoassay; The situation of the four markers was compared within patients of tuberculosis, pulmonary tumor and the healthy control group respectively; The differences of the four markers were compared in patients with three kinds of tuberculosis like pulmonary tuberculosis, obsolete pulmonary tuberculosis and tuberculous pleurisy; The differences of the four markers in the sample of serum and in the sample of pleuroperitoneal effusion of tuberculosis patients were also compared. 【Results】 Contents of NSE and CA125 in serum of tuberculosis patients were obviously higher than those of the healthy control, and the difference is significant（P＜0.05）; CA125 of tuberculosis patients was even higher than that of pulmonary tumor patients （P＜0.05）; There were no difference among patients with different kinds of tuberculosis with the exception of CEA（P＜0.05）; Contents of CEA and NSE in serum sample were significantly higher than those in pleuroperitoneal effusion（P＜0.05）, while contents of CYE211and CA125 in serum sample were remarkably higher than those in pleuroperitoneal effusion sample（P＜0.05）.【Conclusions】CA125 can be considered as an indicator of differentiation and diagnosis of tuberculosis. The result can be more accurate through the collection and detection of serum sample. The results would be more accurate if serum sample is collected and detected. Besides, NSE can also be chosen as an indicator of differentiation and diagnosis of tuberculosis diseases, whose optimal originality of sample collection shall come from pleuroperitoneal effusion.
2015, Vol. 32 
