Abstract：【Objective】To investigate the occurrence and progress of serum creatinine and urea nitrogen in ischemiareperfusion of mice kidney injury.【Methods】Male mice (C57BL/6J) used as subjects were randomly distributed in three groups: the ischemiareperfusion group (IR), the sham surgery group (S) and the control group (C), and the SCr and UN levels of the 3 groups at different time points and the their kidney /lung tissue pathological damage were detected and analyzed.【Results】Levels of SCr and UN showed no significant difference in the Group C and the Group S (P>0.05). From 0h to 7d following reperfusion, the SCr and UN levels gradually increased and then decreased, and reached the peak value 24h after reperfusion . The interstitial damage score of renal tubules and pathological damage score of lung injury at different time points presented comparatively no significant difference between group C and group S (P >0.05). The IR Group presents the same tendency ,increasing first ,than decreasing ,the pathological grading of renal tubular interstitial injury reached the peak value 24h after reperfusion; Pathological damage score of lung injury reached the peak value in 48～72 h.【Conclusion】The mice model of ischemiareperfusion renal injury is one steady animal model for research of Acute kidney injury（AKI）， and ischemia AKI may induce pulmonary inflammatory reaction, and bring out acute kidney injury（AKI）as well.
2015, Vol. 32 
