摘要【目的】研究腹腔镜下胆囊切除术（LC）手术期间输注不同剂量晶体液对患者的影响。【方法】选取2012年1月至2014年9月间156例在本院接受LC手术患者，采用随机数字表的方法分为限制组与非限制组，每组78例。术中限制组和非限制组分别注复方乳酸钠5 mL/(kg•h)和30 mL/(kg•h）。观察记录两组患者的心率（HR）、平均动脉压（MAP）以及并发症发生率；采用视觉模拟评分（VAS）评定患者术后1 h 、6 h 、24 h的疼痛程度。【结果】限制组患者术后6 h的VAS评分以及多汗症状的患者显著高于非限制组；其他不良反应两组之间无明显差异。两组患者之间MAP、HR变化以及住院时间无明显差别(P＞0.05)。【结论】在LC术中输液剂量与非限制组比较，限制组能够加重患者术后疼痛程度，增加术后多汗的发生率。两种输液剂量对患者MAP和HR变化无明显影响，且不影响患者术后住院时间。
Abstract：【Objective】To investigate the effects of total dose of crystalloid solution infusion during surgery in patients undergoing laparoscopic cholecystectomy.【Methods】A total number of 156 cases of patients undergoing laparoscopic cholecystectomy in our hospital from January 2012 to September 2014 were randomly and equally divided into restricting group and opening group by random number table, resulting in 78 cases in each group. Patients in restricting group were infused Lactated Ringer's solution 5 mL/(kg•h), while patients in opening group were infused 30 mL/(kg•h). Heart rate (HR), mean artery pressure (MAP), and complication rate were recorded. Visual analogue scale (VAS) was used to evaluate the pain scale at 1, 6, 24 hours postoperatively.【Results】The VAS scores and hidrosis symptom in restricting group were significantly higher than that in opening group at 6 hours postsurgery (P<0.05). No statistic significant difference on HR, MAP, and hospital stays was observed between two groups (P＞0.05).【Conclusion】Restricting Lactated Ringer's solution infusion during surgery could aggravate postoperative pain and hidrosis symptoms when compare to nonrestriction of infusion. Both methods have no impacts on HR, MAP, and hospital stays.
吴雪兰1 仵正2. 腹腔镜下胆囊切除术患者术中晶体液的输注剂量研究[J]. 医学临床研究, 2015, 32(8): 1474-1476.
WU Xuelan, WU Zheng. Study on Total Dose of Crystalloid Solution Infusion during Surgery in Patients Undergoing Laparoscopic Cholecystectomy. JOURNAL OF CLINICAL RESEARCH, 2015, 32(8): 1474-1476.
2015, Vol. 32 
