Abstract：[Objective]To explore whether dexmedetomidine can reduce the requirement for propofol and remifentanil during breast cancer operation .[Methods]A total of 60 American Society of Anesthesiologists physical status Ⅰ ~ Ⅱ patients received either dexmedetomidine (1 μg/kg over 10 min followed by a continuous infusion of 0 .4 μg/kg/h until tumor removal) or comparable volumes of saline as a placebo .Propofol and remifentanil require‐ments were recorded and analyzed .Changes in mean arterial pressure ,heart rate and bispectral index (BIS) were recorded at operation room (T0 ) ,before anesthesia induction (T1 ) ,1 min pre‐intubation (T2 ) ,30 min during sur‐gery (T3 ) ,end of surgery (T4 ) and 5 min post‐extubation (T5 ) .[Results]All patients completed the study .The propofol dosage required for anesthetic maintenance was 29% (with a 95% confidence interval ,18~40) and it was lower in patients on dexmedetomidine [2 .0 (1 .3~ 3 .4) vs 3 .1(2 .2~4 .7) mg/(kg ? h) ,P = 0 .005] .And remifentanil dosages were also significantly different [0 .16(0 .09~0 .21) vs 0 .10(0 .07~0 .15)μg/(kg?h) ,P=0 .03] .The incidence of adverse events ,including hemodynamic instability and delayed recovery ,was comparable with and without dexmedetomidine .[Conclusion]Dexmedetomidine administration significantly reduces the re‐quirement for both propofol and remifentanil during anesthetic induction and maintenance .
引用本文:
董航. 右美托咪定对乳腺癌患者术中瑞芬太尼和丙泊酚用量的影响[J]. 医学临床研究, 2015, 32(1): 97-99.
DONG Hang. Requirements of Propofol and Remifentanil with Dexmedetomidine During Breast Cancer Surgery. JOURNAL OF CLINICAL RESEARCH, 2015, 32(1): 97-99.
2015, Vol. 32 
