摘要目的观察注射用醋酸亮丙瑞林微球（贝依）治疗子宫腺肌病合并不孕的临床效果。方法对因子宫腺肌病合并不孕接受贝依超促排卵后，行体外受精‐胚胎移植（IVF‐ET ）治疗的60例患者（观察组）的临床资料进行回顾性分析，另选取同期因输卵管因素及其他原因不孕行IVF‐ET治疗的子宫正常者60例作为对照组，记录观察组经贝依（3．75 mg／次，每28天1次）治疗后子宫体积的变化，并比较两组患者IVF‐ET结局。结果①观察组经过2～6次的贝依治疗后，子宫体积由治疗前的（178±75）cm3缩小至治疗后的（85±66）cm3，差异有统计学意义（ P ＜0．05）。② IVF‐ET 结局：观察组的胚胎种植率（38．8％）、临床妊娠率（53．5％）和流产率（4．3％）与对照组相比（分别为35．3％，52．8％，3．6％）差异无显著性（均 P ＞0．05）。③观察组患者经IVF‐ET治疗后妊娠成功者的受精率（76．1％）、双原核率（67．8％）及优质胚胎率（63．4％）均高于妊娠失败者（分别为61．4％、60．8％、50．5％），差异均有统计学意义（ P ＜0．05）。结论贝依能显著缩小子宫腺肌病患者的子宫体积，对合并不孕行IVF‐ET治疗的患者，经治疗后能够获得理想的助孕结局。
Abstract：[Objective] To observe the clinical efficacies of leuprorelin acetate microspheres for uterine ade‐nomyosis with infertility .[Methods] A total of 60 infertile patients with uterine adenomyosis (observation group) undergoing in vitro fertilization embryo transplant (IVF‐ET) ovum induction after using leuprorelin ac‐etate microspheres were studied retrospectively .Another 60 infertile patients with tubal factors were enrolled as control group .The volumes of uterus and outcomes of IVF‐ET were compared between two groups .[Re‐sults] ① Volume of uterus :In observation group after 2~6 courses of therapy (3 .75 mg/28 days) ,the mean uterine volume shrank from (178 ± 75) to (85 ± 66) cm3 ( P <0 .05);② Outcome of IVF‐ET :The rate of embryo implantation ,clinical pregnancy and abortion between observation group (38 .8% ,53 .5% ,4 .3% ) and control group (35 .3% ,52 .8% ,3 .6% ) had no significant difference ( P > 0 .05);③ In observation group ,the rate of fertilization ,two pronuclear and superior embryo in patients with successful pregnancy (76 .1% ,67 .8% ,63 .4% ) after IVF‐ET were higher than those with failed pregnancy (61 .4% ,60 .8% , 50 .5% ) .[Conclusion] Leuprorelin acetate microspheres may shrink the volume of uterine adenomyosis and improve the outcomes of pregnancy in patients undergoing IVF‐ET .
2015, Vol. 32 
