Abstract：[Objective] To explore the expression levels of the inhibitor of differentiation 2(Id‐2) and epi‐thelial cadherin(E‐cadherin) in rectal cancer and its relation with clinicopathological characteristics .[Methods]Immunohistochemical method was used to observe the expression levels of Id‐2 and E‐cadherin in rectal cancer tissue and normal tissue adjacent to cancer .Spearman correlation test was used to analyze the correlation be‐tween Id‐2 and E‐cadherin expression .The correlation of positive expression rate of Id‐2 and E‐cadherin with clinicopathological indicators of rectal cancer was analyzed .[Results] The positive expression rates of Id‐2 in rectal cancer tissues and normal tissues adjacent to cancer were 48 .33% and 71 .67% respectively ,and the positive expression rate of E‐cadherin was 71 .67% and 46 .67% ,respectively .Spearman correlation test showed that there was negative correlation between Id‐2 expression and E‐cadherin expression .There was sig‐nificant difference in the expression levels of Id‐2 and E‐cadherin of rectal cancer among different differentia‐tion ,TNM stage and lymph node metastasis( P<0 .05) ,but there was no significant difference among differ‐ent age and sex( P>0 .05) .[Conclusion]The expression levels of Id‐2 and E‐cadherin are closely related with the occurrence and development of rectal cancer .High expression of Id‐2 in rectal cancer may promote tumor invasion and metastasis through E‐cadherin pathway .
2015, Vol. 32 
