Abstract：[Objective] To explore the clinical efficacies and adverse reactions of cetuximab plus FOLFOX or FOLFIRI chemotherapy in the treatment of advanced colorectal cancer .[Methods] A total of 80 patients with advanced colorectal cancer patients were randomly divided into A and B groups ( n=40 each) .Group A received cetuximab plus FOLFOX regimen while group B cetuximab plus FOLFIRI chemotherapy .And their immediate outcomes ,quality of life and adverse reactions after 6 weeks were recorded and compared .[Re‐sults] There were insignificant inter‐group differences in efficiency or life quality improvement rate ( P >0 .05) .For both groups ,the diameter and thickness of tumor significantly decreased as compared with pre‐treatment ( P <0 .05) .But the inter‐group difference was insignificant ( P >0 .05) .Occurrences of diarrhea and neurotoxicity had significant inter‐group differences ( P <0 .05) .[Conclusion]Cetuximab plus FOLFOX or FOLFIRI has similar efficacies for advanced colorectal cancer .Only individual differences exist in adverse reactions .
2015, Vol. 32 
