Abstract：Objective]To observe the effect of atorvastatin on the levels of hypersensitive C‐reactive pro‐tein(hsCRP) ,hypersensitive cardiac troponin T (hs‐cTnT ) and the prognosis in patients with coronary heart diease(CHD) and chronic heart failure(CHF) .[Methods]Totally 100 patients with CHD and CHF were ran‐domly divided into observation group( n=50) and control group( n =50) .The control group was given con‐ventional medication of anti‐heart failure strategies ,while the observation group received additional atorvasta‐tin 20mg daily based on the conventional treatment .hsCRP and hs‐cTnT were determined before and after 1 month of treatment .The incidence of major adverse cardiovascular events(MACE) and rehospitalization rate were recorded during 1‐year follow up after treatment .[Results]Compared with control group ,the levels of hsCRP and hs‐cTnT in observation group were decreased more significantly after treatment for 1 month[(3 .02 ± 0 .53)mg/L vs .(3 .88 ± 0 .64)mg/L ,(0 .018 ± 0 .009)ng/mL vs .(0 .029 ± 0 .008)ng/mL ,both P<0 .05] . Compared with control group ,MACE and rehospitalization rate in observation group during 1‐year follow up were even decreased[15 .6% vs .21 .7% ,26 .7% vs .37 .0% ,both P<0 .05] .[Conclusion]Atorvastatin can reduce the levels of inflammatory factors and myocardial injury ,and improve the prognosis of patients with CHD and CHF .
2014, Vol. 31 
