摘要目的 了解重症腺病毒肺炎（ADVP）患儿临床特点及免疫功能情况。方法 回顾性分析2013年1月至2013年12月期间101例重症 ADVP患儿和122例非重症 ADVP患儿临床特点及免疫相关指标资料。结果 重症ADVP患儿男性多于女性，冬春季节易发；重症组与非重症组ADVP患儿住院天数、中性粒细胞、C反应蛋白和降钙素原比较，差异有统计学意义（ P ＜0．05）。重症组患儿CD3、CD4降低构成比分别高于非重症组，两者之间的差异有统计学意义（ P ＜0．05） ，而重症组CD8升高构成比低于非重症组，两者之间的差异有统计学意义（ P ＜0．05）。结论 重症ADVP患儿体内存在较强的炎症过程，免疫应答性降低，免疫功能紊乱，临床上应加强相关指标早期检测，并尽早给予干预和综合治疗，控制病情进展。
Abstract：Objective] To understand clinical characteristics and T lymphocyte subsets of severe adenovirus(ADV) pneumonia in children .[Methods]Clinical characteristics and immune‐related indicators of 101 pediatric patients with se‐vere ADV pneumonia and 122 pediatric patients with non‐severe ADV pneumonia from Jan .2013 to Dec .2013 were ana‐lyzed retrospectively .[Results] Among pediatric patients with severe ADV pneumonia ,male patients were more than fe‐male patients .Severe ADV pneumonia mainly occurred in winter and spring .There were significant differences in hospital day ,neutrophil ,c‐reactive protein(CRP) and procalcitonin(PCT) between severe ADV pneumonia group and non‐severe ADV pneumonia group( P<0 .05) .The constituent ratios of the decreasing of CD3 and CD4 in pediatric patients with severe ADV pneumonia were higher than those in pediatric patients with non‐severe ADV pneumonia ,and there was sig‐nificant difference( P<0 .05) .The constituent ratio of the increasing of CD8 in severe ADV pneumonia group was lower than that in non‐severe ADV pneumonia group ,and there was significant difference( P <0 .05) .[Conclusion]Pediatric patients with severe adenovirus pneumonia have strong inflammatory process ,the decreased immunologic responsiveness and immunity function disturbance .Early detection of the correlative indicators should be strengthened in clinical practice . Intervention and comprehensive treatment should be given to control the development of the disease .
引用本文:
罗力妍%饶花平. 儿童重症腺病毒肺炎临床特点及T淋巴细胞亚群分析[J]. 医学临床研究, 2014, 31(11): 2186-2188.
LUO Li-yan%RAO Hua-ping. Analysis of Clinical Characteristics and T Lymphocyte Subsets of Severe Adenovirus Pneumonia in Children. JOURNAL OF CLINICAL RESEARCH, 2014, 31(11): 2186-2188.
2014, Vol. 31 
