Abstract：Objective] To explore the efficacy of methylprednisolone pulse therapy for children with electrical status epilepticus in sleep(ESES) .[Methods]A total of 31 pediatric patients with epilepsy and ESES in pediatric outpatient de‐partment of our hospital from May 2007 to April 2013 were chosen and randomly divided into treatment group( n=16) and control group( n=15) .The treatment group was given methylprednisolone pulse therapy ,oral prednisone and con‐ventional antiepileptics valproate .The control group was only given oral valproate .All patients were followed up for 6 months .The results were analyzed .[Results]In treatment group ,12 patients were effective ,and the efficiency was 75% ,and the incidence of drug adverse reaction was 25 .7% .In control group ,15 patients were effective ,and the effi‐ciency was 46 .6% ,and the incidence of drug adverse reaction was 22 .8% .There was significant difference in the effi‐ciency between two groups( P<0 .05) ,but there was no significant difference in the incidence of drug adverse reaction rate between two groups( P>0 .05) .[Conclusion]Compared with conventional antiepileptics ,methylprednisolone pulse therapy for pediatric patients with ESES has obvious efficacy ,but the side effect of hormone therapy on pediatric patients should be paid attention .
引用本文:
张小清. 甲基强的松龙冲击治疗儿童睡眠中癫痫性电持续状态的临床疗效观察[J]. 医学临床研究, 2014, 31(11): 2184-2186.
ZHA NG Xiao-qing. Observation on Clinical Efficacy of Methylprednisolone Pulse Therapy for Children with Electrical Status Epilepticus in Sleep. JOURNAL OF CLINICAL RESEARCH, 2014, 31(11): 2184-2186.
2014, Vol. 31 
