Abstract:Objective] To explore the correlation of homocysteine(HCY) level with polycystic ovary syn‐drome(PCOS) and early pregnancy abortion(EPL) .[Methods]Totally 123 patients with PCOS including 65 patients with one or more than one abortion within 12 weeks(PCOS abortion group) and 58 patients with nor‐mal pregnant history(PCOS non‐abortion group) were collected .Other 147 patients with one or more than one abortion within 12 weeks but without PCOS (non‐PCOS abortion group) were selected in the same period . HCY level was detected by enzymatic cycling method and compared among 3 groups .[Results] The level of HCY in PCOS abortion group was obviously higher than that in PCOS non‐abortion group and non‐PCOS abor‐tion group ,and that in non‐PCOS abortion group was markedly higher than that in PCOS non‐abortion group , and there was significant difference( P<0 .05) .[Conclusion]High HCY level is a risk factor for EPL and can be used as the indicator of early pregnancy outcome .