Abstract：Objective]To explore the relationship of hepatitis B virus(HBV) cccDNA with serum HBV DNA and HBeAg in liver tissues of patients with hepatitis B .[Methods]HBV cccDNA and serum HBV DNA in liver tis‐sues of patients with hepatitis B were detected by real‐time fluorescence quantitative polymerase chain reaction ,and serum HBeAg was detected by chemiluminescence method .[Results]HBV cccDNA in liver tissue was positively cor‐related with serum HBV DNA( r=0 .806 ,P<0 .01) ,but was not correlated with serum HBeAg( r=0 .219 ,P<0 .05) .[Conclusion]Virus replication in serum HBeAg positive group is more active than that in serum HBeAg nega‐tive group .Negative HBVDNA can not fully reflect HBV replication in liver tissues ,but the detection of HBV cccD‐NA in liver tissues can accurately reflect the replication of intrahepatic HBV .
基金资助:湖南省卫生厅科研基金(B2008-077)
引用本文:
黄维亮%徐丹%谢元林. 肝组织HBVcccDNA与HBV复制水平的相关性分析[J]. 医学临床研究, 2014, 31(11): 2108-2110.
HUA NG Wei-liang%XU Dan%XIE Yuan-lin. Analysis of the Relationship Between HBV cccDNA and HBV Replication Level in Liver Tissues. JOURNAL OF CLINICAL RESEARCH, 2014, 31(11): 2108-2110.
2014, Vol. 31 
