Abstract：To explore clinical efficacy of laparoscopy combined with gonadotropin-releasing hormone agonists (GnRH-a) for the treatment of moderate or severe endometriosis .[Methods]Clinical data of 50 patients with endometriosis in Hunan provincial people's hospital from Mar .2010 to March 2013 were analyzed retrospectively .According to the treatment methods ,all patients were divided into group A and group B .Preoperative combined with postoperative treatment group (group A ,n=15) was given subcutaneous injection with GnRH-a for 2~3 times before laparoscopy and re-injection for 3 times after laparoscopy .Postoperative treatment group(group B ,n =35) was given subcutaneous injection with GnRH-a for 3~6 times after laparoscopy .All patients were followed up for 12 months after operation .Operation time ,intraoperative blood loss ,post-operative recovery ,pain symptom visual analog scale (VAS ) ,recurrence and adverse reaction were compared between two groups .[Results] The operation time in group A and group B were (65 ± 12)min and (92 ± 16)min ,respectively .The amount of bleeding in group A and group B were (105 ± 12)mL and (190 ± 29)ml ,respectively .The time of out-of-bed activity and anus exhaust time in group A after operation were earlier than those in group B .The VAS scores in group A and group B at 12-month follow up after operation were decreased from preoperative 3 .7(1 .7~6 .5) and 3 .2(1 .4~6 .4) points to 1 .6(1 .0~3 .6) and 1 .6(1 .1~3 .5) points ,respectively .The recurrence rates in group A and group during follow up were 7% (1/15) and 6%(2/35) ,respectively .There was no significant difference between two groups .[Conclusion] Laparoscopy combined with pre-operative and postoperative GnRH-a therapy for the treatment of moderate or severe endometriosis can shorten the operation time ,decrease intraoperative blood loss and promote postoperative recovery .However ,laparoscopy combined with preopera-tive and postoperative GnRH-a therapy has the same efficacy in improving postoperative pain and reducing the recurrence rate as the postoperative GnRH-a therapy .
2014, Vol. 31 
