摘要【目的】观察依帕司他联合前列地尔治疗糖尿病周围神经病变（DPN ）的临床疗效。【方法】将88例2型糖尿病（T2DM ）DPN的患者随机分为对照组与观察组，各44例，两组患者均严格控制饮食、适量运动、口服降糖药或注射胰岛素控制血糖，甲钴胺注射液0．5 mg肌注，每日1次。在此基础上，观察组加用依帕司他50 mg口服，每日3次；前列地尔20μg＋0．9％氯化钠注射液100 m L静脉滴注，每日1次。疗程均为2周。【结果】观察组患者自觉症状改善总有效率（97．7％）显著高于对照组（72．7％）（ P ＜0．05）；两组神经传导速度（NCV）均明显改善，观察组优于对照组，差异具有统计学意义（ P ＜0．01）。【结论】依帕司他、前列地尔及甲钴胺注射液联合治疗DPN效果显著。
Abstract：To observe clinical efficacy of epalrestat combined with alprostadil for the treatment of diabetic perineuropathy(DPN) .[Methods] Totally 88 patients with type 2 diabetes mellitus(T2DM) peripheral neuropathy were randomly divided into control group ( n =44) and observation group( n = 44) .Patients in two groups received strict diet control ,appropriate exercise ,oral blood glucose lowering drug or insulin injection to control blood glucose ,and also intramuscular injection with mecobalamin 0 .5mg once daily .On the basis of the treatment of the control group ,the observation group additionally received oral epalrestat 50mg 3 times per day and alprostadil 20 μg+ 0 .9% sodium chloride by intravenous injection once daily .The treatment course was 2 weeks .[Results] The total effective rate of the improvement of subjective symptoms in observation group (97 .7% ) was significantly higher than that in control group(72 .7% )( P<0 .05) .Motor nerve conduction velocity (MNCV) in two groups was obviously improved ,and the improvement in observation group was better than control group , and there was significant difference ( P < 0 .01) .[Conclusion] The combination of epalrestat ,alprostadil and mecobalamine injection is markedly effective in the treatment of DPN .
引用本文:
高四红%郑桃林%何伟. 依帕司他联合前列地尔治疗2型糖尿病周围神经病变的疗效[J]. 医学临床研究, 2014, 31(8): 1569-1571.
GAO Si-hong%ZHENG Tao-lin%HE-Wei. Analysis of the Efficacy of Epalrestat Combined with Alprostadil for the Treatment of Type 2 Dia-betic Perineuropathy. JOURNAL OF CLINICAL RESEARCH, 2014, 31(8): 1569-1571.
2014, Vol. 31 
