摘要【目的】探讨绝经后2型糖尿病（T2DM ）合并骨质疏松（OP）妇女雌激素水平及骨密度的变化及其相关性。【方法】120例绝经后女性T2DM患者根据骨密度值分为骨密度正常组即T组（62例），骨质疏松组即P组（58例）。另选取60例血糖及骨密度均正常的绝经后女性作为正常对照组，即N组（60例）。比较三组骨代谢、糖代谢及性激素等指标。【结果】P组骨碱性磷酸酶（sBA P ）、骨钙素（sOC ）、Ⅰ型胶原交联C 端肽（sCTx）和尿Ⅰ型胶原交联N 端肽（uNTx）明显低于 T 组。P组与 T 组、N组比较，血清卵泡刺激素（FSH）、促黄体激素（L H ）升高，雌二醇（E2）下降（ P＜0．05）。相关性分析显示，患者O P与糖尿病病程、年龄、糖化血红蛋白（HbA1C）、空腹血糖（FPG）、FSH、LH、uNTx与肌酐（Cr）呈显著负相关，与sBAP、sOC、sCTx无相关性。【结论】绝经后T2DM妇女骨质疏松与糖代谢及雌激素水平有关。
Abstract：To explore the changes of estrogen level and bone density among postmenopausal women with type 2 diabetes mellitus(T2DM ) and osteoporosis (OP) and their correlation .[Methods] Postm-enopausal women were divided into T2DM group(group T ,n=62) ,T2DM with osteoporosis group(group P , n =58) and normal control group(group N ,n=60) .Bone metabolism ,glucose metabolism ,sex hormone and other indicators among three groups were compared .[Results]Bone alkaline phosphatase(sBAP) ,osteocalcin (sOC) ,type I collagen cross-linked C end peptide(sCTx) and urine type I collagen cross-linked N end peptide (uNTx) of group P were obviously lower than those of group T .Compared with group T and group N ,serum FSH and LH were elevated ,but E2 was decreased in group P( P <0 .05) .Correlation analysis showed that bone mineral density (BMD) had significantly negative correlation with the duration of diabetes ,age ,HbA1C , FPG ,FSH ,LH and uNTx/Cr ,but no correlation with sBAP ,sOC and sCTx .[Conclusion]Osteoporosis of postmenopausal women with T2DM is related to glucose metabolism and estrogen level .
2014, Vol. 31 
