Abstract：To explore clinical significance of umbilical blood gas analysis ,C-creative protein (CRP) and brain injury in the diagnosis and prognosis evaluation of neonatal asphyxia .[Methods] A total of 60 neonates with asphyxia in our department from Sept .2011 to Dec .2012 were chosen and divided into mild asphyx-ia group( n=36) and severe asphyxia group( n=24) .In the same period ,30 healthy full-term neonates in our de-partment were selected as control group .Umbilical arterial blood of all neonates was drawn and treated by antico-agulation by heparin for blood gas analysis .Other femoral venous blood was drawn to detect CRP level .The inci-dence of hypoxic ischemic encephalopathy and mortality was used to assess the prognosis of patients in two groups .[Results] PH and PaO2 in umbilical arterial blood of mild and severe asphyxia groups were decreased significantly , while PaCO2 and BE in umbilical arterial blood and plasma CRP in femoral vein of mild and severe asphyxia groups were significantly higher than those of control group( P <0 .05) .By comparison between mild group and severe group ,the severer the asphyxia ,the more significant the changes( P <0 .05) .The incidence of hypoxic ischemic encephalopathy and mortality were related with the degree of asphyxia .Compared with mild asphyxia group ,the incidence and mortality in severe asphyxia group were increased significantly ( P<0 .05) .[Conclusion] The degree of neonatal asphyxia is closely related with acid-base balance disturbance and hypoxic ischemic encephalopathy . The synthetic evaluation by combining Apgar score ,umbilical blood gas analysis and plasma CRP can be used in the diagnosis and prognosis of neonatal asphyxia .
引用本文:
谭峰云. 脐血血气分析、C反应蛋白检测在新生儿窒息诊断中的临床意义[J]. 医学临床研究, 2014, 31(8): 1545-1547.
TAN Feng-yun. Clinical Significance of Umbilical Blood Gas Analysis and C-creative Protein in the Diagnosis of Neonatal Asphyxia. JOURNAL OF CLINICAL RESEARCH, 2014, 31(8): 1545-1547.
2014, Vol. 31 
