Abstract：To explore the necessity and feasibility of twice intensity modulated radiation thera-py(IMRT ) plans for locally advanced nasopharyngeal carcinoma through the dosiology comparison of IMRT therapy plan by stages for twice .[Methods]A total of 50 patients with locally advanced nasopharyngeal carci-noma were chosen as the research objects and randomly divided into experimental group and control group with 25 patients in each group .The patients in two groups were treated by chemotherapy for 2~4 periods ,and then IMRT radiotherapy .The experimental group was given twice IMRT plan design ,while the control group was given once IMRT plan design .The dose changes of target area and the surrounding sensitive organs in two groups were observed and compared .[Results] Mean dose(Dmean) and V30 of bilateral parotid in control group were obviously higher than those in experimental group ,and there was significant difference between two groups( P <0 .05) .Dmax and V50 of brain stem and spinal cord in control group were obviously higher than those in experimental group ,and there was significant difference between two groups ( P<0 .05) .[Con-clusion]The twice IMRT plans for the treatment of locally advanced nasopharyngeal carcinoma have a certain advantage for ensuring radiation dose of target area and normal tissue dose and protecting parotid function and important organs such as brain stem and spinal cord effectively .
基金资助:广东省中山市卫生局科研项目(项目编号2013J004)
引用本文:
叶奕菁. 两次调强适形放射治疗计划治疗局部晚期鼻咽癌的临床疗效[J]. 医学临床研究, 2014, 31(8): 1497-1499.
YE Yi-jing. Clinical Efficacy of Twice Intensity Modulated Radiation Therapy Plans for Locally Advanced Nasopharyngeal Carcinoma. JOURNAL OF CLINICAL RESEARCH, 2014, 31(8): 1497-1499.
2014, Vol. 31 
