摘要【目的】探讨CD133、CK19在鼻咽癌组织中的表达情况及临床病理意义。【方法】采用免疫组化法检测112例鼻咽癌及20例正常对照组中CD133、CK19的表达，并分析其临床意义。【结果】CD133在鼻咽癌组织中表达高于正常组织，在原发癌与转移癌之间有显著性差异（ P ＜0．01）；其表达与患者年龄、性别、病理分型及是否伴有颈部淋巴结转移等临床病理特征均无统计学差异。CK19在鼻咽癌组织中表达与正常组织无明显差异，但在原发癌组与转移癌组之间、伴和不伴颈部淋巴结转移组之间表达均有显著性差异（ P ＜0．01）。【结论】CD133可能在诱导鼻咽癌转移方面起重要作用，可作为鼻咽癌干细胞较特异的表面标记物；CK19表达与肿瘤转移有关，但不宜作为鼻咽癌干细胞特异标记物。
Abstract：To explore the expressions of CD133 and CK19 in nasopharyngeal carcinoma and their clini-copathological significance .[Methods]Immunohistochemical method was used to detect the expressions of CD 133 and CK19 in 112 cases of nasopharyngeal carcinoma and 20 cases of normal tissues .Clinical significance was analyzed .[Re-sults]The expression of CD133 in nasopharyngeal carcinoma was higher than that in normal tissue ,and there was sig-nificant difference between primary carcinoma and metastatic carcinoma ( P < 0 .01) ,but there was no significant difference in the expression of CD133 among groups with different age ,sex ,pathological type and cervical lymph node metastasis .There was no significant difference in the expression of CK 19 between nasopharyngeal carcinoma tissues and normal tissues( P<0 .01) ,but there was significant difference between primary carcinoma and metastatic carci-noma or cervical lymph node metastasis and no cervical lymph node ( P<0 .01) .[Conclusion]CD133 may play an im-portant role in the induction of nasopharyngeal carcinoma metastasis ,and can be regarded as one of the specific mark-ers of nasopharyngeal carcinoma stem cells .CK19 expression is associated with tumor metastasis ,but not suitable to be used as the specific maker of nasopharyngeal cancer stem cells .
2014, Vol. 31 
