Abstract：To explore the application value of high-flux hemodialysis(HFHD) in patients with end-stage renal disease(ESRD) .[Methods]Clinical data of 136 ESRD patients undergoing hemodialysis for more than 1 year were collected .According to ultrafiltration coefficient of dialyzer ,all patients were divided into low-flux[ultrafiltration coefficient was 11 .3 mL/(h · mmHg)] 8LR group(group A) ,high-flux[ultrafil-tration coefficient was 50 mL/(h · mmHg)] PS15 group(group B) and high-flux[ultrafiltration coefficient was 71 mL/(h · mmHg)] 17R group(group C) .Blood urea nitrogen(BUN) ,creatinine ,serum phosphorus and potassium clearance ,serum intact parathyroid hormone(iPTH),β2-microglobulin(β2-MG),serum albumin (ALB) ,leptin ,homocysteine ,vitamin B12 and other indicators were compared among 3 groups .The incidence of complications such as joint disease ,carpal tunnel syndrome and cardiovascular diseases in 3 groups after di-alysis were analyzed and compared .[Results] There was no significant difference in blood BUN ,serum creati-nine ,serum phosphorus ,serum potassium and other small molecular substances among 3 groups( P>0 .05) . The clearance rates of iPTH ,β2-MG ,ALB ,leptin ,homocysteine ,vitamin B12 and other middle or giant mo-lecular substances in group B and group C were better than group A ( P>0 .05) .The clearance rate of middle or giant molecular toxin in group C was the highest( P >0 .05) .The incidence of complications such as joint disease ,carpal tunnel syndrome and cardiovascular disease in group B and C was lower than that in group A ( P<0 .05) ,but the incidence of hypotension in group B and C was higher than that in group A ( P <0 .05) . There was no significant difference in infection rate and mortality among 3 groups( P >0 .05) .[Conclusion]The clearance effect of HFHD on small molecular substances is similar to low-flux hemodialysis(LFHD) ,but its effect on middle or giant molecular substances is obviously better than LFHD ,and can reduce the incidence of joint disease ,carpal tunnel syndrome and cardiovascular disease .But the incidence of adverse reactions such as hypotension should be paid attention .
2014, Vol. 31 
