Abstract：Objective To explore the relationship of plasma soluble myeloid cell triggering receptor-1 (sTREM-1) and gene expression with the severity of patients with acute pancreatitis .[Methods]A total of 32 patients with mild acute pancreatitis (MAP) ,25 patients with severe acute pancreatitis (SAP) and 10 healthy volunteers in our hospital from Aug .2011 to Aug .2013 were enrolled in the study .Enzyme-linked immu-nosorbent assay(ELISA) was used to detect plasma level of sTREM-1 at 1 ,3 and 7 days after admission .The expression of TREM-1 gene was examined by using reverse transcriptase polymerase chain reaction (RT-PCR) . APACHE Ⅱ and SOFA scores were used for assessing the condition of patients .[Results] Plasma levels of sTREM-1 in MAP group at 1 ,3 and 7 days after admission were (386 .24 ± 190 .79)ng/L ,(237 .22 ± 118 .64) ng /L and (143 .34 ± 92 .23)ng/L respectively ,and those in SAP group were (849 .56 ± 412 .31)ng/L , (674 .61 ± 347 .47)ng /L and (419 .56 ± 241 .57)ng/L respectively ,and there were significant differences be-tween two groups( P <0 .01) .Plasma levels of sTREM-1 were positively correlated with APACHE Ⅱ and SOFA score( r =0 .645 ,P <0 .05;r =0 .713 ,P <0 .05) .[Conclusion] Plasma levels of sTREM-1 is posi-tively correlated with the severity of patients with AP ,but the expression of TREM-1mRNA gene in SAP group is not increased .
2014, Vol. 31 
