摘要【目的】探讨分析冠状动脉粥样硬化性心脏病（CHD）患者血清胱抑素C（CysC）、CA125和骨保护素（OPG）的水平变化及临床意义。【方法】选取本院158例经冠状动脉造影确诊的 CHD 患者作为观察组（CHD组），另选95例健康人作为健康对照组。分别应用免疫比浊法、化学免疫发光法和ELISA法比较不同组别和不同病变支数患者的CysC、CA125、OPG 水平。【结果】与健康对照组比较，CHD组CysC、CA125、OPG水平明显升高（ P ＜0．05或 P ＜0．01）；单支、双支、多支病变组3组血清CysC、CA125、OPG 水平逐渐升高，左室射血分数（LVEF）逐渐下降，且差异均有显著性（ P ＜0．05或 P ＜0．01）；NYHAⅠ级、Ⅱ级、Ⅲ级、Ⅳ级组血清CysC、CA125、OPG水平逐渐升高，LVEF逐渐下降，且差异均有显著性（ P＜0．05或 P＜0．01）。CysC、CA125、OPG 水平均与冠脉病变支数、心功能级别呈正相关（ P ＜0．01），与 LVEF呈负相关（ P ＜0．01）。【结论】联合检测血浆CysC、BMG、OPG 水平不仅能评价心功能受损程度，而且有助于早期发现CHD和有助于冠脉病变严重程度的判断及预后判断。
Abstract：Objective To explore the changes of serum levels of cystain C (CysC) ,CA125 and osteoprote-gerin(OPG) in patients with coronary heart disease(CHD) and their clinical significance .[Methods]A total of 158 CHD patients in our hospital were chosen as experimental group .Other 95 healthy subjects were chosen as healthy control group .Serum levels of CysC ,CA125 and OPG were compared among different groups and dis-eased vessels by using immunoturbidimetry ,chemiluminescence immunoassay and ELISA .[Results] Com-pared with healthy control group ,serum levels of CysC ,CA125 and OPG in CHD group were obviously in-creased( P <0 .05 or P<0 .01) .Serum levels of CysC ,CA125 and OPG in single ,double and multiple vessel disease groups were gradually increased ,while left ventricular ejection fraction (LVEF) was gradually de-creased ,and there was significant difference( P<0 .05 or P<0 .01) .Serum levels of CysC ,CA125 and OPG level in NYHA Ⅰ ,Ⅱ ,Ⅲ and Ⅳ groups were gradually increased ,but LVEF was gradually decreased ,and there was significant difference( P <0 .05 or P <0 .01) .Serum levels of CysC ,CA125 and OPG were posi-tively correlated with the number of coronary disease vessels and cardiac function classification ( P <0 .01) , and negatively correlated with LVEF ( P <0 .01) .[Conclusion] Serum levels of CysC ,CA125 and OPG can not only evaluate the degree of cardiac function impairment ,but also is helpful for early diagnosis of CHD ,as-sessment of the severity of coronary artery disease and prognosis .
引用本文:
孙硕%肖创清%石坚. 冠心病患者血清胱抑素C、CA125和骨保护素检测的临床意义[J]. 医学临床研究, 2014, 31(7): 1335-1340.
SUN Shuo%XIAO Chuang-qing%SHI Jian. Clinical Significance of the Detection of Serum Cystatin C,CA125 and Osteoprotegerin in Pa-tients with Coronary Heart Disease. 医学临床研究, 2014, 31(7): 1335-1340.
2014, Vol. 31 
