摘要【目的】探讨亚临床甲状腺功能减退（甲减）与2型糖尿病（T2DM ）慢性并发症的相关性。【方法】选择 T2DM 伴发亚临床甲减患者42例（甲减组），随机另取无亚临床甲减的T2DM 患者50例（对照组），比较两组生化指标及并发症发生率。【结果】甲减组患者在年龄、性别比、糖尿病病程及冠心病发生率均明显高于对照组（ P ＜0．05）。甲减组总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、24 h尿白蛋白排泄率（UAER）、超敏 C 反应蛋白（hs-CRP）、促甲状腺激素（TSH）、甲状腺过氧化物酶抗体（TPO-Ab）、甲状腺球蛋白抗体（TG-Ab）水平明显高于对照组，而踝肱指数（ABI）、E峰（心脏快速充盈期）与A峰（心脏缓慢充盈期）比值（E/A）低于对照组（ P ＜0．05）。除糖尿病视网膜病变（DR）差异无显著性外，甲减组糖尿病肾病（DN ）、糖尿病周围神经病变（DPN ）及糖尿病外周动脉病变（PAD ）发生率均显著高于对照组。【结论】T2DM患者易并发亚临床甲减，而亚临床甲减可能影响糖尿病慢性并发症的发生。
Abstract：Objective To explore the correlation between subclinical hypothyroidism and chronic complications of type 2 di-abetes mellitus(T2DM ) .[Methods] Totally T2DM patients with subclinical hypothyroidism (hypothyroidism group) were cho-sen .Other 50 T2DM patients without subclinical hypothyroidism (control group) were chosen randomly .Biochemical indexes and complications were compared between two groups .[Results] Age ,sex ratio ,duration of diabetes mellitus and the inci-dence of coronary heart disease in hypothyroidism group were obviously higher than those in control group .The levels of total cholesterol(TC) ,triglyeride(TG) ,low density lipoprotein cholesterol(LDL-C) 24h-urinary albumin excretion rate(UAER) , high sensitive C-reactive protein(hs-CRP) ,thyroid stimulating hormone(TSH) ,thyroid peroxidase antibody(TPO-Ab) and thyroglobulin antibody(TG-Ab) in hypothyroidism group were obviously higher than those in control group ,but ankle/brachial index(ABI) and the ratio of E peak(cardiac rapid filling period) to A peak(cardiac slow filling period) in hypothyroidism group were lower than those in control group( P<0 .05) .There was no significant difference in the incidence of diabetic retinopathy (DR) between two group .The incidence rates of diabetic nephropathy (DN) ,diabetic polyneuropathy(DPN) and diabetic pe-riphery artery disease(PAD) in hypothyroidism group were significantly higher than those in control group [Conclusion] Pa-tients with T2Dm is easy to have subclinical hypothyroidism .Subclinical hypothyroidism may affect the occurrence of chronic complications of diabetes mellitus .
2014, Vol. 31 
