Abstract：Objective To observe and compare the short-term efficacy and adverse reaction of nedaplatin and docetaxel combination chemotherapy regimen vs .cisplatin and docetaxel combination chemotherapy regimen for the treatment of patients with advanced non-small cell lung cancer(NSCLC) .[Methods] According to chemotherapeutics ,70 patients with NSCLC in our hospital were divided into nedaplatin combined with docetaxel group ( n=36) and cisplatin combined with docetaxel group ( n=34) .Nedaplatin group was given nedaplatin 25 mg/(m2 · d) at d1 ~d3 and docetaxel 75mg/m2 at d1 .Cisplatin group was given cisplatin 25 mg/(m2 · d) at d1 ~d3 .The course was 21 days .After 2 cycles of chemotherapy ,the efficacy and adverse reaction were evaluated by WHO standard .[Results] In nedaplatin group ,1 patient was complete remission(CR) ,and 14 pa-tients were partial remission(PR) ,and 18 patients were stable(SD) ,and 3 patients were progression(PD) ,and the effective rate(RR) was 41 .7% (15/36) .In cisplatin group ,there were CR in 1 patient ,PR in 13 patients ,SD in 18 patients and PD in 2 patients ,and the RR was 41 .2% (14 /34) .There was no significant difference in effective rate between two groups ( P >0 . 05) .The rate of gastrointestinal tract reaction in nedaplatin group and cisplatin group was 5 .6% (2/36) and 29 .4% (10/34) re-spectively ,and there was significant difference between two groups( P<0 .01) .The rate of renal toxicity in nedaplatin group and cisplatin group was 0% (0/36) and 5 .9% (2/34) respectively ( P <0 .01) .The rate of leucopenia in nedaplatin group and cisplatin group was 72 .2% (26/36) and 70 .6% (24/34) ,but there was no significant difference between two groups ( P >0 .05) .[Conclusion] The effective rate of nedaplatin combined with docetaxel regimen for the treatment of NSCLC is not lower than that of cisplatin combined with docetaxel regimen .The gastrointestinal toxicity of nedaplatin combined with docetaxel reg-imen is less than that of cisplatin combined with docetaxel regimen .The main adverse reaction is bone marrow suppression . There is no difference in leucopenia between two regimens .The decreasing of platelet in nedaplatin combined with docetaxel regimen is more obvious than that in cisplatin combined with docetaxel regimen .
基金资助:湖南省卫生厅基金项目(B2013-087)
引用本文:
赵惠萍%严文辉. 奈达铂联合多西他赛治疗晚期非小细胞肺癌的临床疗效观察[J]. 医学临床研究, 2014, 31(7): 1280-1282.
ZHAO Hui-ping%YAN Wen-hui. Clinical Efficacy of Nedaplatin Combined with Docetaxel for the Treatment of Advanced Non-small Cell Lung Cance r. 医学临床研究, 2014, 31(7): 1280-1282.
2014, Vol. 31 
