Abstract：[Obj ective]To explore clinical significance of central vein-arterial partial pressure difference of carbon di-oxide(Pcv-aCO2 )in the assessment of further fluid resuscitation for severe acute pancreatitis(SAP)patients with central venous oxygen saturation(ScvO2 )>70% who receive fluid resuscitation at acute phase.[Methods]Totally 47 SAP pa-tients with ScvO2>70% who received early fluid resuscitation in ICU from Feb.2013 to Oct.2013 were chosen.Ac-cording to Pcv-aCO2 with the threshold of 6mmHg at grouping(T1 ),all patients were divided into low Pcv-aCO2 group (group A,n=24)and high Pcv-aCO2 group(group B,n=23).Pcv-aCO2 at 12h after resuscitation(T2 )was measured again.[Results]There was significant difference in lactic acid(LA)between group A and group B at T1 [(3.35±0.49 mmol/L)vs.(4.46±1.18)mmol/L](P<0.01),but there was no significant difference in ScvO2 between two groups [(72.92±2.21)% vs.(74.43±3.94)%](P>0.05).The clearance of lactate acid(LAC)in group A from T1 to T2 was higher than that in group B(P<0.01).Pcv-aCO2 at T1 and T2 had linear correlation with LA(r=0.523,0.537, all P<0.01),and good negative correlation with LAC(r=-0.49,0.54,all P<0.01).[Conclusion]Although the target value of ScvO2 70% is up to the standard,SAP patients receiving fluid resuscitation have insufficient tissue perfu-sion.Pcv-aCO2>6mmHg can be used as the index of further fluid resuscitation of SAP patients with standard ScvO2 after early resuscitation.
2014, Vol. 31 
